Saitowitz is currently professor of Architecture at the University of California, Berkeley, and is a Principal with Natoma Architects Inc. based in San Francisco, California.
Saitowitz is well-known and influential in the Bay area architecture scene. He is known for his "monochromatic" and "machine-like" architecture. His design for the Beth Sholom Synagogue (2008) in San Francisco garnered international praise and awards, such as the High Commendation Award, Religion & Contemplation at the 2008 World Architecture Festival 2008. At the same time, the Synagogue received critiques from local residents.
The Tampa Museum of Art, designed by Saitowitz, won the American Architecture Award from Chicago Athenaeum: Museum of Architecture and Design and the European Centre for Architecture Art Design and Urban Studies in 2010.