Susan Greenfield, Baroness Greenfield
|The Baroness Greenfield|
Susan Adele Greenfield|
1 October 1950
Hammersmith, London, England, UK
|Alma mater||St Hilda's College, Oxford|
|Spouse(s)||Peter Atkins (m. 1991–2005)|
|Thesis||Origins of acetylcholinesterase in cerebrospinal fluid (1977)|
|Doctoral advisor||Anthony David Smith|
Susan Adele Greenfield, Baroness Greenfield CBE FRCP (born 1 October 1950) is a British scientist, writer, broadcaster, and member of the House of Lords. Her research has focused on the treatment of Parkinson's disease and Alzheimer's disease. She is also interested in the neuroscience of consciousness and the impact of technology on the brain.
She was also chancellor of Heriot-Watt University in Edinburgh between 2005 and 2013. From 1998 to 2010, she was director of the Royal Institution of Great Britain. In September 2013, she co-founded the biotech company Neuro-bio Ltd, where she is Chief Executive Officer.
Greenfield's mother, Doris (née Thorp), was a dancer and a Christian, and her father, Reginald Myer Greenfield, was an electrician who was the son of a first-generation Yiddish-speaking Jewish immigrant from Austria; her grandmothers never spoke and she said of them, "the prejudice was equally vociferous on both sides".
She attended the Godolphin and Latymer School, where she took A levels in Latin, Greek and ancient history, and maths. The first member of her immediate family to go to university, she was initially admitted to St Hilda's College to read Philosophy and Psychology, but changed course and graduated with a first-class degree in experimental psychology. As a Senior Scholar at St Hugh's College, Oxford, she completed her DPhil degree in 1977 under the supervision of Anthony David Smith on the Origins of acetylcholinesterase in cerebrospinal fluid.
She then held a junior research fellowship at Green College, Oxford between 1981 and 1984.
Greenfield's research is focused on brain physiology, particularly on the brain mechanisms of Parkinson's and Alzheimer's diseases, but she is also known as a populariser of science. Greenfield has written a range of books about the brain, regularly gives public lectures, and appears on radio and television.
Since 1976, Greenfield has published some 200 papers in peer-reviewed journals, including studies on the basic brain mechanisms involved in addiction and reward, i.e. relating to dopamine systems and related neurochemicals. She investigated the brain mechanisms underlying Attention Deficit Hyperactivity Disorder (ADHD) as well as the impact of environmental enrichment.
In 1994, she was invited to be the first woman to give the Royal Institution Christmas Lectures, then sponsored by the BBC. Her lectures were titled "Journey to the centre of the brain". She was appointed Director of the Royal Institution in 1998. The post was abolished in 2010. The Royal Institution had found itself in a financial crisis following a £22m development programme led by Greenfield and the Board. The project ended £3 million in debt. Greenfield subsequently announced that she would be taking her employers to an employment tribunal and her claim would include discrimination, but the case was settled out of court.
Greenfield's two main posts at Oxford were as Tutorial Fellow in Medicine at Lincoln College Oxford, and Professor of Synaptic Pharmacology. Between 1995 and 1999, she gave public lectures as Gresham Professor of Physic in London. Greenfield was Adelaide's Thinker in Residence for 2004 and 2005.
As a result of her recommendations, South Australian Premier Mike Rann made a major funding commitment, backed by the State and Federal Governments and the private sector, to establish the Royal Institution of Australia and the Australian Science Media Centre in Adelaide.
She has explored the relevance of neuroscience knowledge to education and has used the phrase "mind change", an umbrella term comparable to "climate change", encompassing diverse issues involved in the impact of the 21st-century environment on the brain.
In 2013 she co-founded a biotech company called Neuro-bio Ltd to develop diagnostic tests and therapeutics for Alzheimer's disease. Her lab had found that the C terminus of acetylcholinesterase can be cleaved and that the resulting peptide can kill neurons; the lab also found that a cyclic peptide analogue could prevent that neuronal death. The company raised around $4 million in 2017.
Greenfield sits in the Parliament of the United Kingdom in the House of Lords as a crossbencher, having no formal political affiliation. Records of Greenfield's activity in the House of Lords indicate abstention on a range of issues. She has spoken on a variety of topics, including education, drugs, and economic empowerment for women.
In 2014, Greenfield published a popular science book called Mind Change: How Digital Technologies are Leaving their Mark on our Brains, describing her ideas about the impact of digital technology.
Impact of digital technology controversy
In press interviews, at public speaking events, as well as in her writing,[non-primary source needed] Greenfield has expressed concerns that modern technology, and in particular social networking sites and video games, may have a significant impact on child development as a factor in autistic-like behaviour.
She noted that Public Health England had related social networking and multiplayer online games to "lower levels of wellbeing", and believed that evidence pointed to a "dose-response" relationship, "where each additional hour of viewing increases the likelihood of experiencing socio-emotional problems". She believed this raised questions about where to draw the boundaries between beneficial and harmful use of such technology, saying that "it would be surprising if many hours per day of screen activity did not influence this neuroplasticity".
However, she has been criticised for failing to publish any research into her theories. Ben Goldacre suggested that "a scientist with enduring concerns about a serious widespread risk would normally set out their concerns clearly, to other scientists, in a scientific paper", and Oxford neuropsychologist Dorothy Bishop has responded in a similar way.
In particular, her statements explicitly linking the increase in internet usage to a rise in autism were criticised in a 2015 editorial in the BMJ written by Bishop, clinical psychologist Vaughan Bell, and psychologist Andrew Przybylski took Greenfield to task, saying that Greenfield's notion had "no basis in scientific evidence" and was "entirely implausible in light of what we know of autism as a neurodevelopmental condition". They expressed concern that her work could be misleading to parents. In response, Greeenfield wrote a letter to the BMJ referencing peer reviewed studies, and saying that "..."Mind Change" is a book presenting the results of numerous peer reviewed studies in neuroscience, psychology, sociology, and epidemiology."
As of 2016, Greenfield has 32 honorary degrees, and has received awards including the Royal Society's Michael Faraday Prize. She has been elected to an Honorary Fellowship of the Royal College of Physicians and the London Science Museum.
In January 2000, Greenfield received the CBE for her contribution to the public understanding of science. Later that year, she was named Woman of the Year by The Observer. In 2001, she became a Life Peer under the House of Lords Appointments Commission system, as Baroness Greenfield, of Ot Moor in the County of Oxfordshire. Like the other people's peers she was self-nominated.
In 2003, she was appointed a Chevalier of the Légion d'Honneur by the French Government. In 2010 she was awarded the Australian Society for Medical Research Medal. She received the British Inspiration award for Science and Technology in 2010.
She is a patron of Alzheimer's Research UK and of Dignity in Dying. She is a founder and trustee of the charity Science for Humanity, a network of scientists, researchers and technologists that collaborates with non-profits to create practical solutions to the everyday problems of developing communities.
- Greenfield, Susan (1995). Journey to the Centers of the Mind: Toward a Science of Consciousness. San Francisco, California: W.H. Freeman. ISBN 0-7167-2723-4.
- Greenfield, Susan (1997). The Human Brain: A Guided Tour (Science Masters Series). New York: Basic Books. pp. 160 pages. ISBN 0-465-00726-0.
- Greenfield, Susan (2002). The Private Life of the Brain (Penguin Press Science). London, UK: Penguin Books Ltd. pp. 272 pages. ISBN 0-14-100720-6.
- Greenfield, Susan (2003). Tomorrow's People: How 21st Century Technology is Changing the Way we Think and Feel. London, UK: Allen Lane. pp. 304 pages. ISBN 0-7139-9631-5.
- Greenfield, Susan (2006). Inside the Body. London, UK: Cassell Illustrated. pp. 288 pages. ISBN 1-84403-500-X.
- Greenfield, Susan (2008). ID: The Quest for Identity in the 21st Century. London, UK: Sceptre. pp. 320 pages. ISBN 0-340-93600-2.
- Greenfield, Susan (2011). You and Me: The Neuroscience of Identity. London, UK: Notting Hill Editions. ISBN 978-1907903342.
- Greenfield, Susan (2013). 2121: A Tale from the Next Century. London, UK: Head of Zeus.
- Greenfield, Susan (2014). Mind Change: How 21st Century Technology is leaving its mark on the brain. London, UK: Random House.
- Greenfield, Susan. A Day in the Life of the Brain: The Neuroscience of Consciousness from Dawn till Dusk.
- Moreton, Cole (11 May 2008). "Susan Greenfield: The girl with all the brains". London, UK: The Independent on Sunday. Retrieved 16 April 2016.
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- Susan Greenfield, Baroness Greenfield on IMDb
- Cragg, S.J.; Hille, C. J.; Greenfield, S.A. (2002). "Functional domains in dorsal striatum of the nonhuman primate are defined by the dynamic behavior of dopamine". The Journal of Neuroscience. 22 (13): 5705–12. PMID 12097522.
- Cragg, S.J.; Hille, C.J.; Greenfield, S.A. (2000). "Dopamine release and uptake dynamics within nonhuman primate striatum in vitro". The Journal of Neuroscience. 20 (21): 8209–17. PMID 11050144.
- Cragg, S.J.; Clarke, D.J.; Greenfield, S.A. (2000). "Real-Time Dynamics of Dopamine Released from Neuronal Transplants in Experimental Parkinson's Disease". Experimental Neurology. 164 (1): 145–53. doi:10.1006/exnr.2000.7420. PMID 10877925.
- Cragg, S.J.; Holmes, C.; Hawkey, C.R.; Greenfield, S.A. (1998). "Dopamine is released spontaneously from developing midbrain neurons in organotypic culture". Neuroscience. 84 (2): 325–30. doi:10.1016/s0306-4522(97)00657-x. PMID 9539208.
- Dickie, B.G.; Holmes, C.; Greenfield, S.A. (1996). "Neurotoxic and neurotrophic effects of chronic N-methyl-D-aspartate exposure upon mesencephalic dopaminergic neurons in organotypic culture". Neuroscience. 72 (3): 731–41. doi:10.1016/0306-4522(95)00611-7. PMID 9157319.
- Threlfell, S.; Greenfield, S.A.; Cragg, S.J. (2010). "5-HT1B receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra". Neuroscience. 165 (1): 212–20. doi:10.1016/j.neuroscience.2009.10.005. PMID 19819310.
- Threlfell, S.; Exley, R.; Cragg, S.J.; Greenfield, S.A. (2008). "Constitutive histamine H2receptor activity regulates serotonin release in the substantia nigra". Journal of Neurochemistry. 107 (3): 745–55. doi:10.1111/j.1471-4159.2008.05646.x. PMID 18761715.
- Dommett, E.J.; Henderson, E.L.; Westwell, M.S.; Greenfield, S.A. (2008). "Methylphenidate amplifies long-term plasticity in the hippocampus via noradrenergic mechanisms". Learning & Memory. 15 (8): 580–86. doi:10.1101/Lm.1092608. PMID 18685149.
- Devonshire, I.M.; Dommett, E.J.; Grandy, T. H.; Halliday, A.C.; Greenfield, S.A. (2010). "Environmental enrichment differentially modifies specific components of sensory-evoked activity in rat barrel cortex as revealed by simultaneous electrophysiological recordings and optical imaging in vivo". Neuroscience. 170 (2): 662–69. doi:10.1016/j.neuroscience.2010.07.029. PMID 20654700.
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- Dommett, E.J.; Devonshire, I.M.; Plateau, C.R.; Westwell, M.S.; Greenfield, S. A. (2010). "From Scientific Theory to Classroom Practice". The Neuroscientist. 17 (4): 382–88. doi:10.1177/1073858409356111. PMID 20484219.
- Khalili, Mustafa; Smith, Elliot; Oltermann, Philip (15 August 2011). "Susan Greenfield: "Mind change is 'an issue that's as important and as unprecedented as climate change"". London: Guardian. Retrieved 17 June 2013.
- Greenfield, Susan. "You And Me: The Neuroscience of Identity". Notting Hill Editions. Retrieved 17 June 2013.
- Koch, Selina; Zipkin, Mark (30 June 2016). "Why Neuro-Bio thinks it's time to revisit the role of AChE in AD". BioCentury.
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|Wikimedia Commons has media related to Susan Greenfield.|
- Susan Greenfield, Baroness Greenfield official website
- Hansard 1803–2005: contributions in Parliament by Baroness Greenfield
- Oxford home page
- Biodata, Social Issues Research Centre]
- Biography, guardian.co.uk
- Biography and Interviews, fortunecity.com
- The Wrong Chemistry, guardian.co.uk
- Audio: Susan Greenfield, Baroness Greenfield conversation, bbc.co.uk
- Knight Ayton Management: Professor Susan Greenfield, knightayton.co.uk
- Neuroscience in the 20th Century, bbc.co.uk, 24 December 1998
- Chaos Theory, bbc.co.uk, 16 May 2002
Dame Anne McLaren
| Fullerian Professor of Physiology
| Director of the Royal Institution