TAX1BP1

TAX1BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M7Q, 4BMJ, 4NLH, 5AAS, 4Z4M, 4Z4K
Identifiers
Aliases	TAX1BP1, CALCOCO3, T6BP, TXBP151, Tax1 binding protein 1
External IDs	OMIM: 605326 MGI: 1289308 HomoloGene: 4395 GeneCards: TAX1BP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	27,844,564 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	52,743,765 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bronchial epithelial cell; ; retinal pigment epithelium; ; amniotic fluid; ; oral cavity; ; right ventricle; ; Achilles tendon; ; caput epididymis; ; middle temporal gyrus; ; corpus epididymis;
	Top expressed in
	corneal stroma; ; olfactory epithelium; ; left colon; ; spermatid; ; seminal vesicula; ; lacrimal gland; ; sciatic nerve; ; duodenum; ; parotid gland; ; plantaris muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	kinase binding; protein binding; metal ion binding;
Cellular component	cytosol; extracellular exosome;
Biological process	regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of type I interferon production; negative regulation of apoptotic process; negative regulation of NF-kappaB transcription factor activity; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8887
	52440
	ENSG00000106052
	ENSMUSG00000004535
	Q86VP1
	Q3UKC1
NM_001079864; NM_001206901; NM_001206902; NM_006024; NM_001362794;
	NM_001362795
	NM_025816; NM_001355595; NM_001355596
NP_001073333; NP_001193830; NP_001193831; NP_006015; NP_001349723;
	NP_001349724
	NP_080092; NP_001342524; NP_001342525
	Wikidata
View/Edit Human	View/Edit Mouse

Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.^[5]

Template:PBB Summary

Interactions

TAX1BP1 has been shown to interact with TNFAIP3^[6] and TRAF6.^[7] TAX1BP1 binds to TNFAIP3 or TRAF6 and suppresses NF-kappaB transcriptional activation.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106052 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004535 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1".
^ De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29). ENGLAND: 4182–90. doi:10.1038/sj.onc.1202787. ISSN 0950-9232. PMID 10435631. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Ling, L; Goeddel D V (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proc. Natl. Acad. Sci. U.S.A. 97 (17). UNITED STATES: 9567–72. doi:10.1073/pnas.170279097. ISSN 0027-8424. PMC 16905. PMID 10920205. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)

Interactions

References

Further reading