TIAF1

TIAF1
Identifiers
Aliases	TIAF1, MAJN, SPR210, TGFB1-induced anti-apoptotic factor 1
External IDs	OMIM: 609517 HomoloGene: 130531 GeneCards: TIAF1
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gastrocnemius muscle; ; Brodmann area 9; ; left ventricle; ; nucleus accumbens; ; putamen; ; hypothalamus; ; amygdala; ; right coronary artery; ; stromal cell of endometrium;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	nucleus;
Biological process	I-kappaB kinase/NF-kappaB signaling; negative regulation of apoptotic process; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9220
	n/a
	n/a
	n/a
	O95411
	n/a
	NM_004740
	n/a
	NP_004731
	n/a
	Wikidata
View/Edit Human

TGFB1-induced anti-apoptotic factor 1 is a protein that in humans is encoded by the TIAF1 gene.^[2]^[3]

Interactions

TIAF1 has been shown to interact with Janus kinase 3^[4] and TRIB3.^[5]

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chang NS, Mattison J, Cao H, Pratt N, Zhao Y, Lee C (February 1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Biochem Biophys Res Commun. 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798.
^ "Entrez Gene: TIAF1 TGFB1-induced anti-apoptotic factor 1".
^ Ji, H; Zhai Q; Zhu J; Yan M; Sun L; Liu X; Zheng Z (April 2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochem. Biophys. Res. Commun. 270 (1). UNITED STATES: 267–71. doi:10.1006/bbrc.2000.2413. ISSN 0006-291X. PMID 10733938. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Zhou, Ying; Li Lu; Liu Qiongming; Xing Guichun; Kuai Xuezhang; Sun Jing; Yin Xiushan; Wang Jian; Zhang Lingqiang; He Fuchu (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5). England: 942–8. doi:10.1016/j.cellsig.2008.01.010. ISSN 0898-6568. PMID 18276110. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)