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Tribbles pseudokinase 3
Symbols TRIB3 ; C20orf97; NIPK; SINK; SKIP3; TRB3
External IDs OMIM607898 MGI1345675 HomoloGene10902 GeneCards: TRIB3 Gene
RNA expression pattern
PBB GE TRIB3 218145 at tn.png
More reference expression data
Species Human Mouse
Entrez 57761 228775
Ensembl ENSG00000101255 ENSMUSG00000032715
UniProt Q96RU7 Q8K4K2
RefSeq (mRNA) NM_001301188 NM_144554
RefSeq (protein) NP_001288117 NP_780302
Location (UCSC) Chr 20:
0.36 – 0.4 Mb
Chr 2:
152.34 – 152.34 Mb
PubMed search [1] [2]

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.[1][2][3]


The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.[3]


TRIB3 has been shown to interact with:


  1. ^ a b Du K, Herzig S, Kulkarni RN, Montminy M (Jun 2003). "TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver". Science 300 (5625): 1574–7. doi:10.1126/science.1079817. PMID 12791994. 
  2. ^ Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci 63 (14): 1632–41. doi:10.1007/s00018-006-6007-9. PMID 16715410. 
  3. ^ a b "Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)". 
  4. ^ a b c d Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110. 
  5. ^ Bowers AJ, Scully S, Boylan JF (May 2003). "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia". Oncogene 22 (18): 2823–35. doi:10.1038/sj.onc.1206367. PMID 12743605. 
  6. ^ Wu M, Xu LG, Zhai Z, Shu HB (July 2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription". J. Biol. Chem. 278 (29): 27072–9. doi:10.1074/jbc.M209814200. PMID 12736262. 

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