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TMI may refer to the phrase "Too much information", or to
Three Mile Island
- Three Mile Island Nuclear Generating Station, a nuclear power station in Pennsylvania, USA
- Three Mile Island accident (1979), at the station
- Three Mile Island accident health effects
- TMI — The Episcopal School of Texas, formerly Texas Military Institute, a preparatory school affiliated with the Episcopal Church
- Ross School of Business, aka Tauber Manufacturing Institute or TMI, graduate program collaboration between the Business and Engineering Schools at the University of Michigan, Ann Arbor
- Teen Missions International, an interdenominational mission organization based in Florida
- The Monroe Institute, a nonprofit education and research organization devoted to the exploration of human consciousness
- Thinking Machines Corporation or Thinking Machines Inc. (TMI), a supercomputer manufacturer
- Time Module (TMI), a member of the Seiko Group, manufactures watch movements
- TMI Associates, a Japanese law firm
- Trans-Mars injection, a propulsive maneuver used to set a spacecraft on a trajectory which will cause it to arrive to Mars.
- Transmarginal inhibition, a mental response to extreme stresses or pain
- Trimethylindium – the most preferred metalorganic indium source for the MOCVD of Compound Semiconductors
- Tool for Microscopic Identification, an online application developed at the University of Minnesota, containing images of sedimentary components viewed using a petrographic microscope
- The Mechanoid Invasion, a role-playing game by Kevin Siembieda.
- The Mortal Instruments, a series of books by Cassandrda Clare.
- "T.M.I.", fourth episode of the 15th season of the American animated television series South Park
- Sam & Mark's TMi Friday (previously called TMi), a Saturday morning show on CBBC
- TMI Hollywood a 2012-2014 variety show from TMI Productions 
- "Too Much Information" (1981), song by The Police on their album Ghost in the Machine (The Police album)
- "Too Much Information" (1993), song by Duran Duran
- "Too Much Information" (2010), song by Railroad Earth
- The Mind's I (album), album by Swedish death metal band Dark Tranquillity
- TMI Mudlib (TMI or TMI-2), online game software named for "The Mud Institute"
- Tales of Monkey Island, a 2009 episodic video game series
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