Talk:COVID-19 vaccine clinical research/Archive 1

Archive 1

Semi-protected edit request on 30 August 2021

According to WP:LEAD, the intro paragraph should summarize the article's most important contents. We would get closer to this goal by expanding the first sentence to read:

COVID-19 vaccine clinical research is the clinical research on COVID-19 vaccines, including their effectiveness and safety.

Then, the same edit should be made to COVID-19 vaccine#Clinical research.

Many thanks — 24.191.101.223 (talk) 20:33, 30 August 2021 (UTC)

 Not done for now: please establish a consensus for this alteration before using the {{edit semi-protected}} template. - FlightTime (open channel) 20:42, 30 August 2021 (UTC)

Looks reasonable to me. I would perhaps suggest broadening it a bit by changing the last part like this: including their safety, efficacy and effectiveness. --Fernando Trebien (talk) 01:08, 2 September 2021 (UTC)

Better now, thanks! —24.191.101.223 (talk) 11:56, 3 September 2021 (UTC)

Splits

I split two tables of templates (efficacy and effectiveness), so it might be reduced size much. Abrilando232 (talk) 00:28, 26 September 2021 (UTC)

removed unrelated content.

I have removed the following paragraphs from the "effectiveness" section due to them being unrelated.

I'm making note of that here in case this information is not already included in any relative articles as i don't have time to go chasing that down right now.

> In addition, unvaccinated COVID-19 patients have strained the capacity of hospitals throughout the country, forcing many to turn away patients with life-threatening diseases.[545][548][549] Some overloaded hospitals have had to put beds in their parking garage,[550] while others lacked both the space and capacity to properly treat new COVID-19 patients.[551][552] In some cases, even after being admitted, their stay was cut short due to a surplus of patients and a shortage of rooms.[553] The situation has led hospitals in states such as Tennessee, Idaho and Oregon to request help from the National Guard.[554][555][556]

> Approximately 900,000 people a day in the U.S. were getting vaccinated during August 2021, with the daily pace of vaccinations accelerating.[559] A large percentage of those are children over the age of twelve, as 68% of parents state that they already have their kids vaccinated or soon will have. For the 45 million children under 12, since they are not yet eligible for the vaccine, surveys indicate that once a vaccine is approved for them there may be a significant surge in the vaccination rate.[560]

--Thesowismine (talk) 01:17, 4 October 2021 (UTC)

Grab bag

This article has lots of material that is not really related to "clinical research". It should be restructured to tell that story or renamed to describe its contents, if that is possible. For example, why is the section on variants transcluded into the article on variants. At worst, it should be the other way around. Lfstevens (talk) 00:05, 29 October 2021 (UTC)

Addition of source for Effectiveness

I'm new so I don't have editing privileges for this page, but I was looking and found a "medical citation needed" where the page discusses vaccine effectiveness against the Delta variant. This peer-reviewed study by the New England Journal of Medicine seems to have a lot more information and data, as well as providing a credible source for this particular question. Again, I'm inexperienced with this so I think it would be better for a more experienced member to properly enter new data and cite this source, especially as this is a sensitive topic.

Study https://www.nejm.org/doi/full/10.1056/nejmoa2108891

Echo532 (talk) 15:07, 13 November 2021 (UTC)

@Echo532: Thank you for the contribution. This subject is quite complicated and there's no single source summarizing it at the moment, so it is not possible to fulfill the "medical citation needed" request. For now it is better to point the reader to a detailed section with all the necessary references. In SARS-CoV-2 Delta variant § Prevention, there are links to the effectiveness of each individual vaccine. For the two data points provided in this study (Pfizer-BioNTech and Oxford-AstraZeneca against symptomatic disease), the articles of these vaccines already reference a study in Scotland with similar results (similar confidence intervals and central estimates) and more data points (it includes effectiveness against asymptomatic infection). --Fernando Trebien (talk) 13:38, 23 November 2021 (UTC)

Efficacy: summary of specific effects

I keep seeing misinformation going around lately saying that the covid vaccines only affect symptoms and don't prevent infection (that is wrong btw: https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7013e3-H.pdf) I think it would be nice if we could have a somewhat up to date summary of what the vaccines are known to do, in a breakdown something like they mention here: https://www.nature.com/articles/s41598-021-94719-y

• vaccine efficacy on SARS-CoV-2 infection susceptibility (VEsusc).
• vaccine efficacy on decreasing the infectiousness of individuals who become infected (VEinf).
• vaccine efficacy on symptoms after infection (VEsymp)
• vaccine efficacy against symptomatic COVID-19 disease (VEdis). -- DKEdwards (talk) 20:25, 17 January 2022 (UTC)

PEIS warning

The following warning appears on the page when you preview it:

Warning: Post-expand include size is too large. Some templates will not be included.

The four SVG images in the "List of authorized and approved vaccines" section appear to be the largest items loaded on the page. To help alleviate the issue, I suggest reducing their size or converting the data to a "Vaccines authorization by country" table. Jroberson108 (talk) 14:18, 24 February 2022 (UTC)

Semi-protected edit request on 4 March 2022

Under section 'Effectiveness', add: People with a weakened immune system, such as organ transplant recipients, are less able to produce neutralising antibodies with only a third doing so. Bionrv (talk) 02:03, 4 March 2022 (UTC) Done.--TZubiri (talk) 06:04, 6 March 2022 (UTC)

References

Efficacy vs efficiency

There are 2 sections with these similar words. Could someone knowledgeable on the topic confirm whether they refer to different things?--TZubiri (talk) 06:05, 6 March 2022 (UTC)