|WikiProject Molecular and Cell Biology||(Rated Stub-class, Mid-importance)|
The term "Contact Inhibition" was coined by Prof. Michael Abercrombie in a paper published in Experimental Cell Research in the early 1950s. The term refers specifically to the inhibition of locomotion of cells, not their growth or division. Contact doesn't "arrest" either cell growth or cell locomotion; what occurs is a slowing or redirection of locomotion. I wish that oncologists really did use differences in contact inhibition to distinguish between normal and cancerous cells. If somebody found a way to do that, it would be an important breakthrough. It is possible that there really are consistent differences in the degree to which normal versus cancer cells are inhibited in either their growth or their invasive locomotion. This article states a plausible guess as if it were a known fact.
The paragraph about cells growing in flasks dying out because of contact inhibition is mistaken. Some dying-out phenomena actually occur ("Hayflick's Phenomenon") but the evidence is that these result from non-replacement of telomeres. I suggest this article should either be improved (made consistent with the published refereed journals) or removed. It is perpetuating some major factual mistakes on an important medical subject.