Talk:Glutamate dehydrogenase

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Merger proposal[edit]

Missing sources/possibly incorrect info[edit]

I'm currently studying a course on the subject and it seems that the claim that the reverse reaction that binds ammonium to alfaketoglutarate doesn't happen in mammals is false, as it is the only way for cells to lower levels of free ammonium ions? There's also no source given for this claim and many online sources indeed state this reaction as primary regulator of excess nitrogen.

Notice : the opposite expression prefered[edit]

you have presented the ability of "Glutamate dehydrogenase" to catalyze the reverse direction in a little bit confusing way: as if you was showing mammals to have "exceptional" inability of a reverse catalysis, whereas I would prefer if you present the ability of lower organisms (prokaryotes and some plants) to catalyze "two directions" as something exceptional ...

in other words: it is more readily accepted that the enzyme catalyze only forward reaction.and having some species catalyzing two opposite reactions by the same enzyme is the weird thing. — Preceding unsigned comment added by Yasir muhammed ali (talkcontribs) 11:47, 8 April 2016 (UTC)

the irreversibility of glutamate DH in vertebrates:[edit]

It seems this apply only to the isoenzyme concerned with urea cycle, not the iso enzyme of the nervous system (GLUD2) Which is concerned with recycling of glutamate neurotransmitter, and is reversible in action. — Preceding unsigned comment added by Yasir muhammed ali (talkcontribs) 18:45, 10 April 2016 (UTC)