Talk:HLA-G

This article was the subject of a Wiki Education Foundation-supported course assignment, between 5 January 2022 and 11 March 2022. Further details are available on the course page. Student editor(s): Immcarle183 (article contribs).

Suggestion: to add a section on HLA-G as a therapeutic target

disclaimer:

I'm new here, so I didn't want to edit the main page directly. I also hold a patent on HLA-G-based therapeutics (for use in autoimmune diseases), but are not associated with the companies/projects that are further developed and which I would thus suggest to add here (use as target in cancer therapy)

TTX-080 is a therapeutic antibody developed by Tizona and Gilead for cancer therapy which blocks the interaction of HLA-G and immunossuppressive receptors https://jitc.bmj.com/content/8/Suppl_3/A419.2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278316/

Invectys is developing CAR-T cells that target HLA-G https://jitc.bmj.com/content/jitc/9/3/e001998.full.pdf?with-ds=yes — Preceding unsigned comment added by Vbruttel (talk • contribs) 20:27, 29 September 2023 (UTC)

Untitled

I'm making the following bibliography

Bibliography

• Loustau. (2020). HLA-G Neo-Expression on Tumors. Frontiers in Immunology., 11. https://doi.org/10.3389/fimmu.2020.01685.
  • This article lists the possible uses of HLA-G as a target for immunotherapies, as the protein is often expressed on cancerous cells. Fronteirs in Immunology is a high impact journal, so this is probably important information.
•   Sabbagh. (2018). The role of HLA-G in parasitic diseases. HLA : Immune Response Genetics., 91(4), 255–270. https://doi.org/10.1111/tan.13196.
  • This article is about HLA-G's role in terms of combating infectious diseases. This is a good article to add to the bibliography because there are many sources about cancer, but this one was unique in its focus.
• Attia, J. V. D., Dessens, C. E., Van De Water, R., Houvast, R. D., Kuppen, P. J. K., & Krijgsman, D.. (2020). The Molecular and Functional Characteristics of HLA-G and the Interaction with Its Receptors: Where to Intervene for Cancer Immunotherapy?. International Journal of Molecular Sciences, 21(22), 8678. https://doi.org/10.3390/ijms21228678.
  • This article focuses in on the structure of HLA-G and how that might affect its function.
•   Li. (2021). HLA-G/sHLA-G and HLA-G-Bearing Extracellular Vesicles in Cancers: Potential Role as Biomarkers. Frontiers in Immunology., 12. https://doi.org/10.3389/fimmu.2021.791535.
  • This recent review discusses possible ways to use HLA-G as a biomarker to test for cancer.

--Immcarle183 (talk) 06:58, 26 January 2022 (UTC)

References