Talk:Homology directed repair

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Genetics task force (assessed as Mid-importance).
	This article is supported by the Molecular and Cell Biology task force (assessed as Mid-importance).

Please add info on "Use in gene editing"

See Talk:CRISPR gene editing#Please add info on non-viral delivery methods & homology-directed repair.

I think there probably should be info on "Use in gene editing" in this article.

For example, it could include some info on this study or its broader type of usage, included in 2022 in science (25 August) like so:

Researchers report the development of a highly effective CRISPR-Cas9 genome editing method without expensive viral vectors, enabling e.g. novel anti-cancer CAR-T cell therapies.^[1]^[2]

Looks like the first reference in this article is about the use in gene editing too, but the article doesn't even mention it.

References

^ Williams, Sarah. "A cellular engineering breakthrough: High-yield CRISPR without viral vectors". Gladstone Institutes. Retrieved 15 September 2022.
^ Shy, Brian R.; Vykunta, Vivasvan S.; Ha, Alvin; Talbot, Alexis; Roth, Theodore L.; Nguyen, David N.; Pfeifer, Wolfgang G.; Chen, Yan Yi; Blaeschke, Franziska; Shifrut, Eric; Vedova, Shane; Mamedov, Murad R.; Chung, Jing-Yi Jing; Li, Hong; Yu, Ruby; Wu, David; Wolf, Jeffrey; Martin, Thomas G.; Castro, Carlos E.; Ye, Lumeng; Esensten, Jonathan H.; Eyquem, Justin; Marson, Alexander (25 August 2022). "High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails". Nature Biotechnology: 1–11. doi:10.1038/s41587-022-01418-8. ISSN 1546-1696. PMID 36008610. S2CID 251843150.

Prototyperspective (talk) 11:47, 8 November 2022 (UTC)[reply]

[1] Williams, Sarah. "A cellular engineering breakthrough: High-yield CRISPR without viral vectors". Gladstone Institutes. Retrieved 15 September 2022.

[2] Shy, Brian R.; Vykunta, Vivasvan S.; Ha, Alvin; Talbot, Alexis; Roth, Theodore L.; Nguyen, David N.; Pfeifer, Wolfgang G.; Chen, Yan Yi; Blaeschke, Franziska; Shifrut, Eric; Vedova, Shane; Mamedov, Murad R.; Chung, Jing-Yi Jing; Li, Hong; Yu, Ruby; Wu, David; Wolf, Jeffrey; Martin, Thomas G.; Castro, Carlos E.; Ye, Lumeng; Esensten, Jonathan H.; Eyquem, Justin; Marson, Alexander (25 August 2022). "High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails". Nature Biotechnology: 1–11. doi:10.1038/s41587-022-01418-8. ISSN 1546-1696. PMID 36008610. S2CID 251843150.

[1]

[2]