|WikiProject Molecular and Cell Biology||(Rated B-class, Mid-importance)|
Lactate dehydrogenase is an enzyme. It is not a base. Lactate, or lactic acid, is what is found in fermented milk. There is no connection between the lactate found in skeletal muscle and that found in fermented milk.
- I got rid of that. Please note that the image is temporarily incorrect (no covalent double bond between C2 and its ketone group in pyruvate), but the wiki will figure out that I uploaded something better. JFW | T@lk 11:47, 19 Apr 2004 (UTC)
Conversion of lactate to pyruvate
I am wondering which LDH isoenzyme catalyzes the conversion of lactate to pyruvate and if it differs among tissues.I know that LDH5 cant do it due to the 4 M subunits it contains.
Response from professional enzymologist: Actually, both isoenzymes can interconvert pyruvate and lactate. It depends on the amount of substrate and cofactor present relative to their respective Km's and the Km's of the products.
Symbol lookup doesn't work
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Question: how is LDH measured?
I'm wondering if anyone (doctors) know of a reason for a massively raised LD. A patient with gallbladder cancer has an LDH of over 10000. I've never seen an LDH of that magnitude before and can't find any literature on it in those levels. Is it likely to simply be a tumour marker for this sort of cancer or is it something? --184.108.40.206 (talk) 03:31, 12 August 2008 (UTC)
isoforms in red blood cells
I think red blood cells can't be assigned uniquely with the LDH1, see http://www.clinchem.org/content/30/8/1353.html — Preceding unsigned comment added by Martombo (talk • contribs) 11:32, 25 April 2012 (UTC)
Could someone change the formula as the picture shows pyruvic acid and lactic acid, but the enzyme substrate is pyruvate and lactate — Preceding unsigned comment added by 220.127.116.11 (talk) 06:24, 24 September 2012 (UTC)
Ethanol induced hypoglycemia
Someone needs to add more details to this section as it does not link nor gives any correlation of NAD+ to hypoglycemia other than simple causality. The introduction of anion gap is also out of topic.Hbk2818 (talk) 19:18, 8 December 2012 (UTC)
I came here to find out exactly what LDH was. I couldn't understand the introduction, so after I figured it out, I rewrote it to make it easier to understand.
Wikipedia is written for the average reader, not the specialist. I read NEJM and Lancet every week, and I couldn't understand it.
Reaction mechanism shows incorrect flow of electrons
The mechanism depicted here shows an arrow with a half peak instead of a full peak which is only used when 1 electron or radical is being transferred. In this reaction, it is a lone pair, regular mechanism and the arrow is incorrect. Mbenzdabest (talk) 05:16, 23 March 2014 (UTC)