Talk:Locus control region

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Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): IANNNNHILLLL.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 02:47, 17 January 2022 (UTC)[reply]

For

For whoever expands this article in the future -- the mouse beta-globin looping study can be found in Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus. Molecular Cell, 10:1453-1465.

The more relevant article is the one dealing with the deletion of the entire ß-globin LCR in mice: it demonstrates that the LCR is not necessary for transcriptional activity of the locus, or for developmental regulation of the genes within it. (Mol Cell. 1998 Oct;2(4):447-55.)Davidiank (talk) 22:20, 29 August 2018 (UTC) Josh[reply]

Plagiarism?

The first line is pretty much word for word the same as the abstract for this article: http://www.ncbi.nlm.nih.gov/pubmed/12384402 "Locus Control Regions" —Preceding unsigned comment added by 128.187.97.4 (talk) 18:19, 1 December 2010 (UTC)[reply]

Page expansion

I am a student editor taking Advanced Genetics at the University of Western Ontario. I am going to be working on this page for an assignment.

In searching for literature relevant to this topic, I was not able to find any articles (review or clinical trial) that was newer than 2012. This may indicate that this concept may have gone out of favour in the scientific community, or that it is not worth the time or financial commitment to study in depth. Nevertheless, there are many articles contending that this concept has relevance to certain genetic conditions. A condition that appears multiple times is β-thalassemia. It is mentioned in this page, but only very briefly. The bulk of my work will therefore be expanding that section of this page, since most of the recent literature appears to be directed towards this condition.

Possible section headers I will be adding/Expanding:

Diseases Related to the LCR -subheader for β-thalassemia

Proposed models of LCR function

Properties of LCRs

IANNNNHILLLL (talk) 18:23, 16 October 2015 (UTC)[reply]

In response to IANNNNHILLLL: The term is actually making a come back in the scientific community especially because there seems to be a growing consensus about the misuse of the relatively new concept of 'super enhancers'. There is growing evidence that what people call superenhncers are actually locus control regions and within a year or two there will be some papers providing evidence for that. It is important that this page remains current (updated) to ensure that there is a proper representation of ideas. It is a little disconcerting to see that the super enhancer wiki page has over 60 citations while the LCR page is at a meager 4! We need to fix this problem. — Preceding unsigned comment added by Rajatsingh24k (talk • contribs) 23:45, 26 May 2016 (UTC)[reply]

Why do they exist?

It would be interesting to mention (if there even is anything to mention) why we think locus control regions even exist. That is, of course, why we think they evolved. BernardoSulzbach (talk) 11:17, 29 January 2022 (UTC)[reply]