|WikiProject Molecular and Cell Biology||(Rated Start-class, High-importance)|
|WikiProject Medicine||(Rated Start-class, Low-importance)|
|This article is/was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Assigned student editor(s): Lisa96liu. Assigned peer reviews: Sazhnyev.|
Proposed changes to the article
Hello. This is an outline of some of the ideas I have to improve this article. Please let me know what you think.
There are four main causes for protein aggregations: mutations in the amino acid sequence, disruptions in the pathway that degrades or refolds the proteins, environmental stresses, and ageing. I would like to restructure this article in a way that describes these four causes in more detail under “Causes.” I feel that this would make the article more organized by clearly sectioning the main points, and by taking away the section “Protein aggregation and Aging” by putting the information in that section into “Causes.” Currently, the article briefly describes these four causes, but does not go into much detail about the biochemistry of the mechanisms. This is something I would like to work on.
With regards to the first cause, mutations in the protein sequence, I would like to describe in more biochemical detail about how this can lead to protein aggregation. Specifically, certain changes in the amino acid sequence can disrupt the electrostatic interactions that hold the protein’s three-dimensional shape together.
For the second cause, the Wikipedia article does go into quite some detail about the cellular processes that regulate protein aggregation, so I will use a lot of the information already there. Nevertheless, I would like to further explain the role Heat Shock Proteins and chaperones play in fixing the protein aggregates.
For environmental stresses, I would like to talk about how heat shock and oxidative stresses can cause the protein to unfold. For instance, I would talk about free radicals in the cell and how they can damage the protein by disrupting certain covalent bonds.
Finally, for the ageing section, I will try to utilize most of the information that is already written in the “Protein aggregation and Aging” section of the article, as it is already pretty well written and thorough.