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188.8.131.52 02:43, 16 March 2007 (UTC)
This sentence is not right. can someone restructure it? possibly to lead to a latter fleshing out of each aspect.
>This explains why many childhood diseases never recur in adulthood (and >if they do, it generally indicates immunosuppression) or failure of a >vaccine.
FDA defines Seroconversion in influenza vaccine 4-fold jump in HI antibody. What do EU & WHO require?
Seroconversion is defined as an increase in HI (Hemagglutination-Inhibition) antibody titer of at least 4-fold, with a minimum post-vaccination HI titer of 1:40.
I believe this refers to results from a Viral Hemagglutination Assay
I believe a 60% seroconversion rate among immunonaieve patients is one of the standards for licensure of a vaccine by the FDA.
– Seroconversion – defined as % subjects with a minimum 4-fold rise in HI titer (e.g., pre-vaccination HI titer < 1:10 and a post vaccination titer > 1:40, or a pre-vaccination titer > 1:10 and a minimum 4-fold rise HI titer) – Seroprotection – defined as % subjects with an HI titer > 1:40
FDA also requires – a specified increase in HI antibody Geometric Mean Titer (GMT) following vaccination.
seroconversion per wiktionary 2011 Feb 27
seroconversion (plural seroconversions)
(immunology) The development of specific antibodies in the blood serum as a result of infection or immunization