Talk:Site-specific recombinase technology

From Wikipedia, the free encyclopedia
Jump to: navigation, search
WikiProject Molecular and Cellular Biology  
WikiProject icon This article is within the scope of the WikiProject Molecular and Cellular Biology. To participate, visit the WikiProject for more information.
 ???  This article has not yet received a rating on the project's quality scale.
 ???  This article has not yet received a rating on the project's importance scale.
 

At present this article exclusively deals with Cre-loxP recombination and as such could be merged into that page. On the other hand, perhaps this article could be expanded to talk about other site-specific recombination systems being utilised in molecular biology such as Flp-FRT or Xer-cer. Blackmetalbaz (talk) 11:19, 10 April 2008 (UTC)


October 23 2013: The fact that, for humans and mice, a small set of orthologues implicated in reproduction, host defence and immunity have been subject to selection and thereby modification should not distract from major compliances which explain the extraortrdinary relevance of murin genome projects (among these EUCOMM). See:

Emes RD, Goodstadt L, Winter EE, Ponting CP.(2003) Comparison of the genomes of human and mouse lays the foundation of genome zoology. Hum Mol Genet. 1;12(7):701-9 http://hmg.oxfordjournals.org/content/12/7/701.long

October 30 3013: Quoted in the article (Ref 14) there is a clear-cut statement emphasizing the value of mouse models regarding the valid regulatory and ethical aspects: "Annotation of the human and mouse genomes has identified more than 20,000 protein-coding genes and more than 3,000 noncoding RNA genes. Together, these genes orchestrate the development and function of the organism from fertilization through embryogenesis to adult life....To determine gene function, mutation of those genes is required in model organisms. The mouse has long been regarded as ideal for this purpose. Conservation of most aspects of mammalian development, anatomy, metabolism, and physiology between humans and mice is underscored by strong one-to-one orthologous relationships between genes of the two species".

While considering quotation of these references directly in the article, I preferred to maintain its central focus, which is devoted to tecnology rather than peripüheral aspects. — Preceding unsigned comment added by Juergen Bode (talkcontribs) 12:23, 30 October 2013 (UTC)

JB