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Earlham Institute

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Coordinates: 52°37′37″N 1°13′08″E / 52.6269°N 1.219°E / 52.6269; 1.219
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The Genome Analysis Centre (TGAC)
File:The Genome Analysis Centre Logo.png
Established3 July 2009[1]
Field of research
DirectorProf Dylan Edwards
AddressNorwich Research Park
LocationColney, Norfolk, England
52°37′37″N 1°13′08″E / 52.6269°N 1.219°E / 52.6269; 1.219
NR4 7UH
Affiliations
Operating agency
Websitewww.tgac.ac.uk

The Genome Analysis Centre (TGAC) is a life science research centre located at the Norwich Research Park (NRP), Norwich, England. TGAC's research areas are broad and cover bioinformatics, computational biology, host pathogen interaction, plant and microbial genomics, and vertebrate health among others.

History

It was established by the Biotechnology and Biological Sciences Research Council in partnership with East of England Development Agency (EEDA), Norfolk County Council, Norwich City Council, South Norfolk Council and the Greater Norwich Development Partnership. It cost £13.5 million, and was built by Morgan Sindall. It was officially opened on 3 July 2009[1] by John Sulston, winner of the 2002 Nobel Prize in Physiology or Medicine, and former Director of the Wellcome Trust Sanger Institute, another genomics research institution.

In early June 2011, it unveiled a supercomputer on its site that has the most powerful processor in the world that runs Red Hat Linux, with six terabytes of RAM.[citation needed] It was installed to crack the structure of the wheat genome, which is five times larger than the human genome.

Launched MISO (Managing Information for Sequencing Operations).

Structure

It is situated on the Norwich Research Park, to the west of Norwich on the former A47 (B1108), and adjacent to the west of the University of East Anglia, next to the River Yare.

Function

The goal of this research centre is to be at the forefront of data intensive science in biology, to be a leader in bioinformatics innovation and the application of genome technology and to enable bioscience through dissemination of the data and technology produced in the institute and in collaboration with external scientists worldwide. It will concentrate on wheat and ryegrass.

Directors

The Genome Analysis Centre (TGAC) has been directed by:

  • Jane Rogers from July 2009 to October 2012;
  • Mario Caccamo from November 2013 to May 2015;
  • Prof Dylan Edwards from July 2015 (Interim Diretor)


Communicating Science

One of the responsibilities of TGAC is to communicate the science it undertakes to a range of audiences, such as the international scientific community, the general public, school children, and students. It runs various programmes throughout the year to deliver this responsibility. TGAC further communicate their work on their blog.

Facilities

Sequencing Platforms

TGAC is equipped with next-generation sequencing platforms for high-throughput sequence generation for research projects and sequence improvement. We engage with platform developers to ensure early access and integration into the institute's portfolio of projects and tools.

  • Illumina HiSeq2000/2500
  • Illumina MiSeq
  • PacBio RSII
  • OpGen Argus
  • Life Technologies Ion Proton

Computing Platform

TGAC deploys and maintains leading edge high-performance computing resources that help keep the UK at the forefront of genomics and computational bioscience. Our heterogeneous computing environment allows researchers to exploit distributed-memory and large shared-memory supercomputers along with GPU, Xeon-Phi and FPGA accelerators, to tackle any computational challenge.

System Compute Blades Sockets per Blade Cores per Socket Total Cores Memory Capacity per Blade Total Memory Capacity Accelerators Interconnect Local Filesystem Storage Operating System Scheduler
SGI UV2000 176 2 8 (Intel Eight-core SandyBridge E5-4650L @ 2.6 GHz) 2816 128GB 22 Terabytes 32 x Xeon-Phi 5110P. 8GB RAM and 60 cores per Phi @ 1.1GHz Numalink 6 110TB CXFS Scratch Space RHEL 6.4 PBS
SGI UV100 (x2) 48 2 8 (Intel Eight-Core Xeon E7-8837 @ 2.66 GHz) 768 128GB 6 Terabytes Numalink 5 110TB CXFS Scratch Space RHEL 6.4 PBS
AMD Opteron Cluster 60 4 8 (AMD Opteron ‘Magny-Cour’ @ 2.3 GHz) 1920 56x128GB, 4x256GB 8 Terabytes 6 x Xeon-Phi 5110P. 8GB RAM and 60 cores per Phi @ 1.1GHz, Tesla GPUs 1/10 GB/s Ethernet 216GB local disk per node, 6x 512GB SSD CentOS v5/6 LSF



References

  1. ^ a b "BBC NEWS | UK | England | Norfolk | Support hope for new genome unit". Retrieved 2012-06-22.
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