Tracheal agenesis is a rare birth defect with a prevalence of less than 1 in 50,000, in which the trachea fails to develop. The defect is normally fatal, although occasional cases have been reported of long-term survival following surgical intervention.
There are three main types of tracheal agenesis, designated Types I, II and III.
In 2013, a case was reported of a South Korean child with tracheal agenesis who had been successfully treated after having been kept alive in an intensive care unit for the first two and a half years of her life. She then had an artificially created trachea implanted that had been created by tissue engineering using her own stem cells. The patient however later died from complications.
- Chiu, T.; Cuevas, D.; Cuevas, L.; Monteiro, C. (1990). "Tracheal agenesis". Southern Medical Journal. 83 (8): 925–930. doi:10.1097/00007611-199008000-00018. PMID 2200137.
- Ergun, S.; Tewfik, T.; Daniel, S. (2011). "Tracheal agenesis: A rare but fatal congenital anomaly". McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students. 13 (1): 10. PMC 3277332. PMID 22363177.
- Watanabe, T.; Okuyama, H.; Kubota, A.; Kawahara, H.; Hasegawa, T.; Ueno, T.; Saka, R.; Morishita, Y. (2008). "A case of tracheal agenesis surviving without mechanical ventilation after external esophageal stenting". Journal of Pediatric Surgery. 43 (10): 1906–1908. doi:10.1016/j.jpedsurg.2008.06.013. PMID 18926230.
- Fuchimoto, Y.; Mori, M.; Takasato, F.; Tomita, H.; Yamamoto, Y.; Shimojima, N.; Hoshino, K.; Koinuma, G.; Morikawa, Y. (2010). "A long-term survival case of tracheal agenesis: Management for tracheoesophageal fistula and esophageal reconstruction". Pediatric Surgery International. 27 (1): 103–106. doi:10.1007/s00383-010-2716-0. PMID 20857299.
- Peter Murray (2013-05-06). "Girl Receives Engineered Trachea Treated With Her Own Stem Cells". Singularity Hub. Retrieved 2013-05-20.
- Katie Moisse (2013-04-30). "Toddler Born Without a Windpipe Gets Artificial Trachea". ABC News. Retrieved 2013-05-20.
- Moisse, Katie (8 July 2013). "Girl Dies After Groundbreaking Trachea Transplant". ABC News. Retrieved 9 February 2016.
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