TrkB IRES

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TrkB IRES
RF00547.jpg
Predicted secondary structure and sequence conservation of IRES_TrkB
Identifiers
SymbolIRES_TrkB
RfamRF00547
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GO0043022
SO0000243
PDB structuresPDBe

The TrkB internal ribosome entry site (IRES) is an RNA element which is present in the 5' UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites.[1]

See also[edit]

References[edit]

  1. ^ Dobson T, Minic A, Nielsen K, Amiott E, Krushel L (2005). "Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5' leader". Nucleic Acids Research. 33 (9): 2929–2941. doi:10.1093/nar/gki605. PMC 1133793. PMID 15908588.

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