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Tryphon was a Greek grammarian.
Tryphon or Trypho may also refer to:
- Tryphon (Turkestanov) (1861–1934), hierarch of the Russian Orthodox Church
- Diodotus Tryphon (fl. 144–138 BC), Seleucid ruler
- Saint Tryphon (disambiguation), several saints
- Salvius Tryphon (fl. c. 100 BC), rebel slave
- Jewish philosopher Trypho (fl. 2nd century), in Dialogue with Trypho, who may be identical with the Rabbi Tarfon