TSPYL5 (gene)

TSPYL5
Identifiers
Aliases	TSPYL5, TSPY like 5
External IDs	OMIM: 614721 MGI: 2442458 HomoloGene: 14134 GeneCards: TSPYL5
Gene location (Human) Chr. Chromosome 8 (human) Band 8q22.1 Start 97,273,488 bp End 97,277,928 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 B3.1 Start 33,684,021 bp End 33,688,030 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula spinal ganglia corpus epididymis superior vestibular nucleus lactiferous duct trigeminal ganglion pons caput epididymis oocyte external globus pallidus Top expressed in spermatocyte amygdala visual cortex hippocampus proper prefrontal cortex piriform cortex nucleus accumbens otolith organ utricle superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus Biological process regulation of growth nucleosome assembly positive regulation of protein kinase B signaling positive regulation of protein ubiquitination cellular response to gamma radiation positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85453 239364 Ensembl ENSG00000180543 ENSMUSG00000038984 UniProt Q86VY4 Q69ZB3 RefSeq (mRNA) NM_033512 NM_001085421 RefSeq (protein) NP_277047 NP_001078890 Location (UCSC) Chr 8: 97.27 – 97.28 Mb Chr 15: 33.68 – 33.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

TSPY like 5 is a protein that in humans is encoded by the TSPYL5 gene.

Further reading

• Jung Y, Park J, Bang YJ, Kim TY (February 2008). "Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers". Lab. Invest. 88 (2): 153–60. doi:10.1038/labinvest.3700706. PMID 18059362.
• Kim EJ, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC, Kim IG (February 2010). "TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway". Biochem. Biophys. Res. Commun. 392 (3): 448–53. doi:10.1016/j.bbrc.2010.01.045. PMID 20079711.
• Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R (January 2011). "TSPYL5 suppresses p53 levels and function by physical interaction with USP7". Nat. Cell Biol. 13 (1): 102–8. doi:10.1038/ncb2142. PMID 21170034. S2CID 288643.
• Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, Schaid DJ, Nakamura Y, Weinshilboum RM (April 2013). "TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression". Mol. Endocrinol. 27 (4): 657–70. doi:10.1210/me.2012-1397. PMC 3607698. PMID 23518928.
• Qiu X, Hu B, Huang Y, Deng Y, Wang X, Zheng F (January 2016). "Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance". Dig. Dis. Sci. 61 (1): 149–57. doi:10.1007/s10620-015-3878-3. PMID 26386860. S2CID 22547345.
• Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V (May 2016). "Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression". Hum. Mol. Genet. 25 (9): 1714–27. doi:10.1093/hmg/ddw043. PMC 4986328. PMID 26911678.
• Lakshmanan I, Salfity S, Seshacharyulu P, Rachagani S, Thomas A, Das S, Majhi PD, Nimmakayala RK, Vengoji R, Lele SM, Ponnusamy MP, Batra SK, Ganti AK (July 2017). "MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53". Clin. Cancer Res. 23 (14): 3906–3917. doi:10.1158/1078-0432.CCR-16-2530. PMC 5511558. PMID 28196872.
• Kumar SR, Bryan JN, Esebua M, Amos-Landgraf J, May TJ (February 2017). "Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma". BMC Cancer. 17 (1): 158. doi:10.1186/s12885-017-3134-7. PMC 5326500. PMID 28235398.
• Shao L, Shen Z, Qian H, Zhou S, Chen Y (December 2017). "Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5". DNA Cell Biol. 36 (12): 1108–1116. doi:10.1089/dna.2017.3904. PMID 28972400.