UPARAP
It has been suggested that this article be merged into Mannose receptor. (Discuss) Proposed since October 2015. |
uPARAP, also known as Endo180, is a membrane protein involved in turnover of extracellular matrix. The name is an acronym for urokinase-type Plasminogen Activator Receptor Associated Protein. Loss of the uPARAP encoding gene MRC2 has been shown to cause Crooked Tail Disease in Belgian Blue Cattle.
References
- Behrendt N (February 2004). "The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling". Biol. Chem. 385 (2): 103–36. doi:10.1515/BC.2004.031. PMID 15101555.
- Fasquelle C, Sartelet A, Li W, et al. (September 2009). "Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle". PLoS Genet. 5 (9): e1000666. doi:10.1371/journal.pgen.1000666. PMC 2739430. PMID 19779552.
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