USS Prime is the name of two ships of the U.S. Navy:
- USS Prime (AM-279), a minesweeper in naval service 1944–46.
- USS Prime (AM-466), minesweeper commissioned in 1954, reclassified as MSO-466 in 1955, stricken in 1976.
|This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.|