U Street or "U" Street is the 22nd of a sequence of alphabetical streets in many cities (or the 21st if "I" or "J" is omitted).
It may refer to:
- U Street (Washington, D.C.), a street in Washington, D.C.
- School of Hard Knocks or "University of the Streets"
- University/65th Street, a station in Sacramento, California
- Street University, a project of the Ted Noffs Foundation in New South Wales, Australia