Uhha-Ziti had two recorded children, Piyama-Kurunta and Tapalazunauli, who were of fighting age as of 1322 BC.
The Hittite king Mursili II in his second campaign season, 1322 BC, attacked Attarimma, Hu[wa]rsanassa, and Suruda on Arzawa's border. Their leaders fled to Arzawa. When the king demanded their extradition, Uhha-Ziti defied him and called him a "child". He also managed to enlist Manapa-Tarhunta of the Seha River Land, but not Maskhuiluwa of Mira.
Mursili put down a Kaska rebellion, and invaded Arzawa. Uhha-Ziti at this time had made his base at Apasa. During Mursili's march, a meteorite struck Apasa and wounded Uhha-Ziti, as recorded in the Annals of Mursili II:
"The mighty Storm God, My Lord, showed his divinely righteous power and hurled a thunderbolt. All of my troops saw the thunderbolt. All the land of Arzawa saw the thunderbolt. The thunderbolt passed (us) and struck the land of Arzawa. It struck Uḫḫa-ziti’s (capital) city Apaša. It settled in Uḫḫa-ziti’s knees, and he became ill."
In his wounded state, Uhha-Ziti could no longer lead the charge; therefore, having allied with the King of Ahhiuwa (most probably Mycenaean Greece)—the first time the "Ahhiya" are recorded with a monarch, he ordered Piyama-Kurunta to take the field at Walma by the Astarpa river. Piyama-Kurunta lost the battle, and Uhha-Ziti and his sons fled to the nearby Ahhiuwa-controlled islands.
Uhha-Ziti died while Mursili was besieging the men of Attarimma, Hu[wa]rsanassa, and Suruda at Puranda.