Updike is a surname of Dutch origin, and is a spelling variant of the Dutch Opdijk, a topographical name meaning someone who lived on a dike. The surname has been present in North America since the settlement of New Netherland in the 17th century. Updike used to be spelled as Updyke and many other ways, but is now most commonly spelled as Updike.
- Daniel Berkeley Updike, American printer and historian of typography.
- John Updike, American novelist, poet, short story writer, art critic, and literary critic.
- Nancy Updike, American public radio producer and writer.
- Ralph E. Updike, a U.S. Representative from Indiana.
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