User:裤裤马鹿/sandbox
Immunology
[edit]Many of studies showed calorie restriction can attenuate the negative effects of aging which is highly connected to the change of immunity in human.[1]T cell functions are well known to be declined with age. A six-month calorie restriction test on humans showed that T cell functions were improved with calorie restriction comparing to baseline. But the positive response became statistical significant only after 30% CR.[2] Cytokine TNF-α and IL-6 which do multi-function in immune system are naturally increased with aging. The over production of them were linked to age-associated disorders. Calorie restriction of old mice showed a decreasing of those cytokines, thus an inhibition of cytokines dysregulation by aging. [3] The experimental autoimmune encephalomyelitis mice also suggested calories restriction can have anti-inflammatory effect with changing of cytokines.[4] Comparing to controlled old mice, calorie restricted old mice had more naive T cell phenotype and more immature NK cell phenotype. [5]
This is a user sandbox of 裤裤马鹿. You can use it for testing or practicing edits. This is not the sandbox where you should draft your assigned article for a dashboard.wikiedu.org course. To find the right sandbox for your assignment, visit your Dashboard course page and follow the Sandbox Draft link for your assigned article in the My Articles section. |
- ^ Most, Jasper; Tosti, Valeria; Redman, Leanne M.; Fontana, Luigi. "Calorie restriction in humans: An update". Ageing Research Reviews. 39: 36–45. doi:10.1016/j.arr.2016.08.005.
- ^ Tanvir Ahmed, Sai Krupa Das, Julie K. Golden, Edward Saltzman, Susan B. Roberts, Simin Nikbin Meydani; Calorie Restriction Enhances T-Cell–Mediated Immune Response in Adult Overweight Men and Women, The Journals of Gerontology: Series A, Volume 64A, Issue 11, 1 November 2009, Pages 1107–1113, https://doi-org.proxy1.cl.msu.edu/10.1093/gerona/glp101
- ^ Ahmed, Tanvir; Das, Sai Krupa; Golden, Julie K.; Saltzman, Edward; Roberts, Susan B.; Meydani, Simin Nikbin (2009-11-01). "Calorie Restriction Enhances T-Cell–Mediated Immune Response in Adult Overweight Men and Women". The Journals of Gerontology: Series A. 64A (11): 1107–1113. doi:10.1093/gerona/glp101. ISSN 1079-5006.
- ^ Piccio, Laura; Stark, Jennifer L.; Cross, Anne H. (2008-10-01). "Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis". Journal of Leukocyte Biology. 84 (4): 940–948. doi:10.1189/jlb.0208133. ISSN 0741-5400. PMID 18678605.
- ^ White, Matthew J.; Beaver, Charlotte M.; Goodier, Martin R.; Bottomley, Christian; Nielsen, Carolyn M.; Wolf, Asia-Sophia F. M.; Boldrin, Luisa; Whitmore, Charlotte; Morgan, Jennifer. "Calorie Restriction Attenuates Terminal Differentiation of Immune Cells". Frontiers in Immunology. 7. doi:10.3389/fimmu.2016.00667.
{{cite journal}}
: CS1 maint: unflagged free DOI (link)