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Psoriasis susceptibility 1 candidate 2 (PSORS1C2) is a protein in humans encoded by the PSORS1C2 gene located on chromosome 6p21.33. PSORS1C2 has the alias chromosome 6 open reading frame 17[1] and is primarily found in the extracellular region[2]. PSORS1C2 is found in mammals[3] and its high expression in the skin is associated with influencing the onset of psoriasis.[4]
Gene
[edit]PSORS1C2 is a protein coding gene and has 2 exons[5] and spans 434 base pairs[6]. It has the alias chromosome 6 open reading frame 17 (C6orf17) and it is located on chromosome 6 (p21.33) with associations to the skin disorder psoriasis[7].
Expression
It is highly expressed within the skin and minimally expressed in the testis[8]. In addition, techniques like the Northern blot analysis have revealed that the expression of the PSORS1C2 gene in mice and pigs are very similar to that of a human[9].
Protein
[edit]PSORS1C2 has a theoretical molecular weight of 15.1 kDa and theoretical pI of 4.5[10]. There are no alternatively spliced RNA variants. In addition, it is primarily located in the extracellular region[11]. It is proline and tryptophan rich with a KR-ED of -24 making it more acidic than average[12].
Post-translational Modifications
SignalIP predicted that there is a signal peptide signal at amino acids 22 and 23 with a cleavage site from amino acids 1 to 22 in the sequence[13].PSORS1C2 has a single acetylation site[14].
Interactions
It is related to a few genes such as CCHR1, CDSN, and PSORS1C1 that aid keratinocyte proliferation regulation, epidermal barrier integrity, and psoriasis susceptibility[15].
Homology and Evolution
[edit]Paralogs
PSORS1C2 has a single paralog called PSORS1C1[16] It is 152 amino acids long and has 2 exons[17]. Similarly to PSORS1C2, it is thought to confer susceptibility to psoriasis and systemic sclerosis[18].
Orthologs
Genomic analysis of chromosome 6 showed PSORS1C2 is only present in mammals[19].
Clinical Significance
[edit]PSORS1C2 in collaboration with antigens on HLA-6 influence the onset of psoriasis[20]
References
[edit]- ^ https://www.genecards.org/cgi-bin/carddisp.pl?gene=PSORS1C2.
{{cite web}}: Missing or empty|title=(help) - ^ https://services.healthtech.dtu.dk/cgi-bin/webface2.cgi?jobid=64C424C4000049211126575D&wait=20.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170679.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170680.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170680.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170680.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170680.
{{cite web}}: Missing or empty|title=(help) - ^ "PSORS1C2 Summary (PSORS1C2 psoriasis susceptibility 1 candidate 2 [Homo sapiens (human])".
- ^ [[1] "OMIM (Online Mendelian Inheritance in Man) entry on PSORS1C2"].
{{cite web}}: Check|url=value (help) - ^ https://web.expasy.org/cgi-bin/compute_pi/pi_tool.
{{cite web}}: Missing or empty|title=(help) - ^ https://services.healthtech.dtu.dk/cgi-bin/webface2.cgi?jobid=64C424C4000049211126575D&wait=20.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ebi.ac.uk/Tools/services/web/toolresult.ebi?jobId=saps-I20230711-160746-0121-75143029-p1m&analysis=summary.
{{cite web}}: Missing or empty|title=(help) - ^ https://services.healthtech.dtu.dk/cgi-bin/webface2.cgi?jobid=64B6C6A9000051750BC7BF61&wait=20.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.phosphosite.org/proteinAction?id=3724276&showAllSites=true.
{{cite web}}: Missing or empty|title=(help) - ^ https://string-db.org/cgi/network?taskId=btiqaTczXah6&sessionId=b9VKR6D7rmeN.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170679.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170679.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170679.
{{cite web}}: Missing or empty|title=(help) - ^ https://www.ncbi.nlm.nih.gov/gene/170679.
{{cite web}}: Missing or empty|title=(help) - ^ [Rubén Queiro, Torre, J. C., Segundo Leiva González, López-Larrea, C., Tomás Tinture, & López-Lagunas, I. (2003). HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis. 30(3), 505–507. Rubén Queiro, Torre, J. C., Segundo Leiva González, López-Larrea, C., Tomás Tinture, & López-Lagunas, I. (2003). HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis. 30(3), 505–507.]
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