User:Ape222/sandbox

Wikipedia pages I've commented on:

https://simple.wikipedia.org/wiki/Talk:Olfactory_system

What I will be adding to the olfactory receptor neuron page:

Desensitization of olfactory neuron

Desensitization of Olfactory Neuron

The olfactory receptor neuron has a fast working negative feedback response upon depolarization. When the neuron is depolarizing, the CNG ion channel is open allowing Sodium and Calcium to rush into the cell. The influx of calcium begins a cascade of events within the cell. Calcium first binds to calmodulin to form CaM. CaM will then bind to the CNG channel and close it, stopping the sodium and calcium influx. CaMKII will be activated by the presence of CaM, which will phosphorylate ACIII and reduce cAMP production. CaMKII will also activate phosphodiesterase, which will then hydrolyze cAMP. The effect of this negative feedback response inhibits the neuron from further activation when another odor molecule is introduced.

Schematic diagram of the negative feedback regulation of olfactory signal transduction in olfactory sensory neurons. Within the olfactory cilia, calcium entry occurs via the activation of CNG channels. Elevated intracellular calcium accelerates inhibition of CNG channels and ACIII, in addition to activating phosphodiestrase (red); calcium and the calcium-binding protein, calmodulin (CaM), bind to and close the CNG channels. Calcium/CaMdependent protein kinase II (CaMKII) phosphorylates ACIII, thereby reducing cAMP production. CaMKII is also known to activate phosphodiesterase PDE1C2, which is enriched in the olfactory cilia, resulting in the hydrolysis of cAMP. Furthermore, PKA and GRK3 are thought to mediate OR desensitization (red arrows). This more or less, and I have a diagram showing this cascade.Ape222 (talk) 00:09, 10 December 2015 (UTC)

Are you still in the class/planning on doing a wikipedia article? Sivart13 (talk) 21:47, 28 November 2015 (UTC) Travis

Hey, I've seen that you've made edits on some pages recently, but you don't have anything in your sandbox yet. I would be more than glad to give you some feedback, but I need something to work with first. If you've done your review already and it's somewhere else, just point me toward it and I can review that. Thanks! Biophysman (talk) 20:18, 29 November 2015 (UTC)

Hey I found your sandbox. I can give feedback too, but I guess I will just wait until you present! Thanks!OMM93 (talk) 11:16, 1 December 2015 (UTC)

Awesome addition. The only thing that I would mention is do you have citations already? Wikipedia users love to read things with citations. I am sure the diagram will be almost as valuable as your addition of text as well. OMM93 (talk) 02:58, 10 December 2015 (UTC)

I think the schematic diagram could really help strengthen the page, but it's hard to tell without being able to see it. I'll leave you the same feedback someone left me, because it's solid advice: this is a very technical section; it would be helpful to make sure you link to all the appropriate pages, like for phosphodiestrase, calmodulin, CaMKII, etc. It seems like you know what you're going to do though. Good luck! Biophysman (talk) 04:52, 10 December 2015 (UTC)

Just reading over your text again. I see that you refer to red arrows in the text, but the diagram is black and white. I am not sure what the red arrows refers too unfortunately. Other than that I think it is a great diagram for sorting things out. I agree with Biophysman as well. Links are easy to do, and some people may want to know what else these intermediates are involved with.OMM93 (talk) 03:50, 13 December 2015 (UTC)