User:Arora.ro/sandbox
 | This is a user sandbox of Arora.ro. You can use it for testing or practicing edits. This is not the sandbox where you should draft your assigned article for a dashboard.wikiedu.org course. To find the right sandbox for your assignment, visit your Dashboard course page and follow the Sandbox Draft link for your assigned article in the My Articles section. |
Cristae are vital in the apoptotic pathway in advanced eukaryotic organisms. Of all cytochrome c present in the mitochondria, more than 85% is found in invaginations of the cristae. Cytochrome c, when released from the outer membrane into the cytoplasm signals apoptosis[1]. Destabilization of the crista structure has been also associated with several neurodegernative diseases. These diseases include Alzheimer's Disease, amyotrophic lateral sclerosis, and Parkinson's disease.[1]
- ^ a b Zick, Michael; Rabl, Regina; Reichert, Andreas S. (2009-01-01). "Cristae formation—linking ultrastructure and function of mitochondria". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Assembly of the Mitochondrial Respiratory Chain. 1793 (1): 5–19. doi:10.1016/j.bbamcr.2008.06.013.