H2-CBD

Coloradochromatography/sandbox
Different versions of H2CBD
Names
	IUPAC name 2'-isopropyl-5'-methyl-4-pentyl-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol or 2-(5-methyl-2-(prop-1-en-2-yl)cyclohexyl)-5-pentylbenzene-1,3-diol
	Other names Hydrogenated CBD, HCBD, HHCBD
Identifiers
CAS Number	?;
PubChem CID	?;
Properties
Chemical formula	C21H32O2
Molar mass	316.5
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

H2CBD, or hydrogenated CBD, was first accessed by the Todd group in 1940 by catalytic hydrogenation of cannabidiol ^[1]. Gallily et al accessed the dihydro-cannabidiol H2CBD in 2006 following testing demonstrating binding affinity to CB1 receptor and their anti-inflammatory capacity ^[2]^[3]. Scialdone treated U87 cells with hydrogenated CBD in mouse models and saw a reduction in tumor weight over a 48-h period^[4].

References

^ Jacob, A.; Todd, A. R. (1940). "119. Cannabis indica. Part II. Isolation of cannabidiol from Egyptian hashish. Observations on the structure of cannabinol". J. Chem. Soc. 119: 649-653. doi:10.1039/jr9400000649.
^ Ben-Shabat, S.; Hanus, L. O.; Katzavian, G.; Gallily, R. (2006). "New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity". J. Med. Chem. 49: 1113-1117. doi:10.1021/jm050709m.
^ Morales, P.; Reggio, P. H.; Jagerovic, N. (2017). "An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol". Front. Pharmacol. 8: 422. doi:10.3389/fphar.2017.00422.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Scialdone, M (2016). "Hydrogenation of Cannabis Oil". {{cite journal}}: Cite journal requires |journal= (help)

[1] Jacob, A.; Todd, A. R. (1940). "119. Cannabis indica. Part II. Isolation of cannabidiol from Egyptian hashish. Observations on the structure of cannabinol". J. Chem. Soc. 119: 649-653. doi:10.1039/jr9400000649.

[2] Ben-Shabat, S.; Hanus, L. O.; Katzavian, G.; Gallily, R. (2006). "New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity". J. Med. Chem. 49: 1113-1117. doi:10.1021/jm050709m.

[3] Morales, P.; Reggio, P. H.; Jagerovic, N. (2017). "An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol". Front. Pharmacol. 8: 422. doi:10.3389/fphar.2017.00422.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[4] Scialdone, M (2016). "Hydrogenation of Cannabis Oil". {{cite journal}}: Cite journal requires |journal= (help)

[1]

[2]

[3]

[4]