User:Ernst.ch/sandbox

I plan to edit the Dose (biochemistry) page by adding sources to the existing information so that it's clear to readers that what is written is true and verifiable. I also plan to add a section about the developments that have occured to advance molecular dosing, such as the device which detects cocaine in blood serum and MEDIC, a device which measures the concentration of drugs in blood continuously, in real time.

Potential addition:

Another approach that’s been investigated recently is dosing on an individualized molecular level, either through conventional delivery systems, nanoparticle delivery, light-triggered delivery, or other less known or used methods. By combining these drugs with a system that detects the concentration of drug particles in the blood, proper dosing could be achieved for each individual patient. Individualized treatment is an integral part of the future of medicine. Research in this field was initiated with monitoring of small-molecule cocaine levels in undiluted blood serum with electrochemical aptamer-based sensing. DNA aptamers with specific targets that fold in response to the analyte in a microfluidic detection system were used to create an electrochemical signal, and researchers tested it on cocaine detection. This research was continued and led to the creation of a product called MEDIC, microfluidic electrochemical detector for in vivo continuous monitoring, developed by faculty at the University of California at Santa Barbara. MEDIC is an instrument that can continuously determine the concentrations of different molecules in the blood. . MEDIC can detect a wide variety of drug molecules and biomarkers, which elevates dosing science dramatically and advances medicine toward more precise and appropriate dosing. In trials, early models of the device failed after about half an hour because the proteins in whole blood clung to the sensors and clogged the components. This problem was solved via a second chamber that allowed a liquid buffer to flow over the sensors with the blood, without mixing or disturbing the blood, so the clogging was prevented but the results remained unchanged. The device is still in clinical trials and actual implementation in medicine is likely years away, however in the interim, its creators estimate that it could also be used in the pharmaceutical industry to allow for better testing in Phase 3 clinical trials.