User:Flemingrjf

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I'm Bobby Fleming. A senior at Saint Louis University. I am using wikipedia for a biology class in Signal Transductions.

I'm editing Wikipedia as part of this assignment and here's a link to my sandbox.

The Wikipedia article I have selected to edit is mTOR as well as the two related articles mTORC1 and mTORC2.

Assignment 4[edit]

For assignment 4, I mostly rebuilt the mTORC1 page by keeping the main content there, but adding much more detail to it as well as vastly updating the citations in terms of year published as well as their content. I am pretty proud of the efforts there so far and feel that the page is almost complete. I also added a history of mTOR to the mTOR page as well. I have added as much as I have could find about mTORC2, but feel with more digging into the literature a review article describing in greater mTORC2 will arise. For the next major assignment in terms of editing, I plan on adding pictures to the mTORC1 article, which includes pathways as well as structure of mTORC1. In addition, I also plan on adding an overall picture of the mTOR pathway, which includes both mTOR complexes as the picture describing the pathway right now seems rather confusing to the casual researcher. Below I have included the more significant diffs as lots of them were very minor (like taking out a word here or there) and can be looked upon by going to the page histories of either mTOR, mTORC1 or mTORC2.

[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]

Assignment 6[edit]

For assignment 6, I added the clinical significance to the mTORC1 page. I am pretty proud with the efforts there. With the clinical aspects, I tried to make them as understandable to the very casual reader as I could. I feel that, hopefully, a reader will be able to pass upon mTORC1, and hopefully become a healthier and overall better person as a result of reading the article. In addition, I have also addressed all of Grace's comments on the talk page for mTORC1. In terms of my revision of the article, I wanted to focus on how mTORC1 was able to influence aging throughout the entire body while referencing its effects on cancer, diabetes, neurodegenerative disease, and cardiovascular disease. In the future, I hope to specifically address these aspects of aging in terms of mTORC1's influence on them. The first priority in future revisions to the mTORC1 article are to create pictures of the different signalling going on as well as get rid of the disambiguity of the links on the page. A rough draft of the picture in regards to signalling has been created on a powerpoint slide, but I am not ready to upload it yet. I will also try to get my article linked with as many related articles as possible, in order to create public interest in this page, because mTORC1 and its signalling seems so consequential for overall human health. One review article I read said that even though on the surface, aging and decline seems to be very complicated, it can all be traced back to mTOR. This may be oversimplifying it, but the point does get across. Below, I have included the more significant diffs to the page. I hope the links work, even though a picture of a lock appears next to them.

[12] [13] [14] [15] [16] [17] [18] [19]



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