From Wikipedia, the free encyclopedia
^ Chen, Jiatong (Steven); Kandle, Patricia F.; Murray, Ian V.; Fitzgerald, Lauren A.; Sehdev, Jasjit S. (2023), "Physiology, Pain" , StatPearls , Treasure Island (FL): StatPearls Publishing, PMID 30969611 , retrieved 2023-11-05 ^ Portenoy, Russell K. (2020-04). "A Practical Approach to Using Adjuvant Analgesics in Older Adults" . Journal of the American Geriatrics Society . 68 (4): 691–698. doi :10.1111/jgs.16340 . ISSN 1532-5415 . PMID 32216151 . ^ Wheeler, Kathleen E.; Grilli, Ryan; Centofanti, John E.; Martin, Janet; Gelinas, Celine; Szumita, Paul M.; Devlin, John W.; Chanques, Gerald; Alhazzani, Waleed; Skrobik, Yoanna; Kho, Michelle E.; Nunnally, Mark E.; Gagarine, Andre; Ergan, Begum A.; Fernando, Shannon (2020-07). "Adjuvant Analgesic Use in the Critically Ill: A Systematic Review and Meta-Analysis" . Critical Care Explorations . 2 (7): e0157. doi :10.1097/CCE.0000000000000157 . PMC 7340332 PMID 32696016 . CS1 maint: PMC format (link ) ^ Hamburger, J.; Beilin, Y. (2019-11-01). "Systemic adjunct analgesics for cesarean delivery: a narrative review" . International Journal of Obstetric Anesthesia . 40 : 101–118. doi :10.1016/j.ijoa.2019.06.009 . ISSN 0959-289X . ^ Tomić, Maja; Pecikoza, Uroš; Micov, Ana; Vučković, Sonja; Stepanović-Petrović, Radica (2018-12-01). "Antiepileptic drugs as analgesics/adjuvants in inflammatory pain: current preclinical evidence" . Pharmacology & Therapeutics . 192 : 42–64. doi :10.1016/j.pharmthera.2018.06.002 . ISSN 0163-7258 . ^ Sidhu, Harpreet S.; Sadhotra, Akshay (2016). "Current Status of the New Antiepileptic Drugs in Chronic Pain" . Frontiers in Pharmacology . 7 . doi :10.3389/fphar.2016.00276 . ISSN 1663-9812 . PMC 4996999 PMID 27610084 . {{cite journal }}: CS1 maint: PMC format (link ) CS1 maint: unflagged free DOI (link )^ Urits, Ivan; Peck, Jacquelin; Orhurhu, Mariam Salisu; Wolf, John; Patel, Riki; Orhurhu, Vwaire; Kaye, Alan D.; Viswanath, Omar (2019-07-29). "Off-label Antidepressant Use for Treatment and Management of Chronic Pain: Evolving Understanding and Comprehensive Review" . Current Pain and Headache Reports . 23 (9): 66. doi :10.1007/s11916-019-0803-z . ISSN 1534-3081 . ^ Sardar, Kawsar; Rashid, Md A.; Khandoker, Mahmudur R.; Khan, Anmn (2016-09). "Anticonvulsants and Antidepressants in Chronic Pain Management" . Journal on Musculoskeletal Ultrasound in Pain Medicine . 2 (3): 90. doi :10.5005/jp-journals-10046-0050 . ISSN 2468-8452 . ^ Alsager, Ahmad; Alsuhaibani, Abdulaziz; Nafisah, Sharafaldeen Bin (2022-08-08). "Use of Diphenhydramine for Pain Management in the Emergency Department: A Systematic Review and Meta-analysis" . The Journal of Medicine, Law & Public Health . 2 (3): 151–158. doi :10.52609/jmlph.v2i3.55 . ISSN 2788-791X . ^ Derry, Christopher J; Derry, Sheena; Moore, R Andrew (2014-12-11). Cochrane Pain, Palliative and Supportive Care Group (ed.). "Caffeine as an analgesic adjuvant for acute pain in adults" . Cochrane Database of Systematic Reviews . 2019 (5). doi :10.1002/14651858.CD009281.pub3 . PMC 6485702 PMID 25502052 . {{cite journal }}: CS1 maint: PMC format (link )^ Arora, Vipin; Campbell, James N.; Chung, Man-Kyo (2021-04-01). "Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain" . Pharmacology & Therapeutics . 220 : 107743. doi :10.1016/j.pharmthera.2020.107743 . ISSN 0163-7258 . PMC 7969397 PMID 33181192 . {{cite journal }}: CS1 maint: PMC format (link )^ Chung, Man-Kyo; Campbell, James N. (2016-12). "Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations" . Pharmaceuticals . 9 (4): 66. doi :10.3390/ph9040066 . ISSN 1424-8247 . PMC 5198041 PMID 27809268 . CS1 maint: PMC format (link ) CS1 maint: unflagged free DOI (link ) ^ Pantoja-Ruiz, Camila; Restrepo-Jimenez, Paula; Castañeda-Cardona, Camilo; Ferreirós, Alexandra; Rosselli, Diego (2022-01-01). "Cannabis and pain: a scoping review" . Brazilian Journal of Anesthesiology (English Edition) . 72 (1): 142–151. doi :10.1016/j.bjane.2021.06.018 . ISSN 0104-0014 . PMC 9373074 PMID 34280454 . {{cite journal }}: CS1 maint: PMC format (link )^ Vučković, Sonja; Srebro, Dragana; Vujović, Katarina Savić; Vučetić, Čedomir; Prostran, Milica (2018). "Cannabinoids and Pain: New Insights From Old Molecules" . Frontiers in Pharmacology . 9 . doi :10.3389/fphar.2018.01259/full . ISSN 1663-9812 . {{cite journal }}: CS1 maint: unflagged free DOI (link )
Outline of proposed changes [ edit ] Provide slightly more detail in introductory section about the role of analgesic adjuvants in multimodal analgesia
Include discussion of the term "multimodal analgesia," maybe rename/add redirect from "multimodal analgesia"
Expand on each individual pharmacologic class, (proposed) mechanisms of pain relief, and indications/contraindications
Considering including other compounds that traditionally are not considered analgesic medications
Considering removing muscle relaxants (cyclobenzaprine/carisoprodol), since they are typically included in multimodal analgesic regimens and there is already some discussion in the pain management page.
Argument for: muscle relaxants are often first or second line for acute musculoskeletal pain
Argument against: muscle relaxants are primarily used for spasticity which may or may not come with pain, may not traditionally thought of as pain medications by the general public (but carisoprodol may be?)
If keeping, should also include discussion on other types of muscle relaxants like methocarbamol
Should at least combine into single entry/section of muscle relaxants
Leaning towards keeping and making a whole separate section on muscle relaxants since the focus of this article is probably "anything that isn't an opioid/tylenol/NSAID"
