User:Inaki Irazabalbeitia/sandbox

(R)-Dysidazirine is a organic compound with formula C₁₉H₃₃NO₂. It was discovered as a natural product in 1988 in the marine sponge Dysidea fragilis^[1]. Chemically it is a 2H-azirine derivative.

(R)-Dysidazirine synthesis was reported for the first time in 1995^[2]. The data for the synthetic compound and natural product perfectly matched. except for the specific rotation. Apparently, the natural (R)-dysidazirine was only 89% optically pure

Dysidazirine exhibits potent in vitro antifungal activity against the pathogenic yeast Candida albicansItalic text. It also inhibits cultured HCT-116 human colon cancer cells.

References[edit]

^ "Despite my high ring strain, I'm pretty stable. What molecule am I?". ACS.org. American Chemical Society. Retrieved 18 November 2022.
^ Davis, Franklin A., Venkat Reddy, G. and Liu, Hu (1995). "Asymmetric Synthesis of 2H-Azirines: First Enantioselective Synthesis of the Cytotoxic Antibiotic (R)-(-)-Dysidazirine". J. Am. Chem. Soc. 117, 12: 3651–3652.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[1] "Despite my high ring strain, I'm pretty stable. What molecule am I?". ACS.org. American Chemical Society. Retrieved 18 November 2022.

[2] Davis, Franklin A., Venkat Reddy, G. and Liu, Hu (1995). "Asymmetric Synthesis of 2H-Azirines: First Enantioselective Synthesis of the Cytotoxic Antibiotic (R)-(-)-Dysidazirine". J. Am. Chem. Soc. 117, 12: 3651–3652.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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