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S cells are cells which release secretin, found in the jejunum and duodenum. They are stimulated by a drop in pH to 4 or below in the small intestine's lumen. The released secretin will increase the secretion of bicarbonate (HCO3) into the lumen, via thepancreas. This is primarily accomplished by an increase in cyclic AMP that activates CFTR to release chloride anions into the lumen. The luminal Cl is then involved in a bicarbonate transporter protein exchange, in which the chloride is reabsorbed by the cell and HCO3 is secreted into the lumen. S cells are also one of the main producers of cyclosamatin.

  • Secretin, a chemical released by S cells.
  • Duodenum, the first part of the small intestine in humans
  • Jejunum, second part of the small intestine in humans

References[edit]

[1][2][3][edit]

  1. ^ al., Koo J , et. "Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å. - PubMed - NCBI". www-ncbi-nlm-nih-gov.proxy.wexler.hunter.cuny.edu. Retrieved 2016-10-25. {{cite web}}: no-break space character in |title= at position 71 (help)CS1 maint: multiple names: authors list (link)
  2. ^ al., Delanoue R , et. "Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor. - PubMed - NCBI". www-ncbi-nlm-nih-gov.proxy.wexler.hunter.cuny.edu. Retrieved 2016-10-25.{{cite web}}: CS1 maint: multiple names: authors list (link)
  3. ^ al., Boraschi P , et. "Secretin-stimulated MR cholangiopancreatography: spectrum of findings in pancreatic diseases. - PubMed - NCBI". www-ncbi-nlm-nih-gov.proxy.wexler.hunter.cuny.edu. Retrieved 2016-10-25.{{cite web}}: CS1 maint: multiple names: authors list (link)