User:Kadamkuan15/sandbox
Ashwini Sharan
Biography[edit] Ashwini Sharan was born in Patna Bihar, in 1970 He migrated to USA with his parents (Guru and Kumud) as an infant in 1971 , lived in NYC and then moved to Edison NJ where he got his High School diploma from J.P.Stevens High School . He got his BS Degree from Bostion University and MD Degree from UMDNJ (University of Medicine and Dentistry , NJ) . He did his residency in Neuro Surgery from University of Connecticut, Hartford CT and Thomas Jefferson University, Philadelphia, PA. He did his fellowship in The Cleveland Clinic Foundation . He married Kanu Priya , MD has 2 daughters Isha and Maansi.
I am an experienced neurosurgeon with a specialty focus in epilepsy surgery, pain and s pinal implants. I have personally operated on over 6000 patients with epilepsy, pain – including Migraine, Parkinson’s Disease and spinal problems. In addition, I successfully administered the projects (e.g. staffing, research projections, budget), collaborated with other researchers, and produced over 150 peer reviewed publications. I hold a number of leadership positions including being the President of the North American Neuromodulation Society – which is the largest education forum for Neuro-modulation worldwide and I am also the President Elect of the Congress of Neurological Surgeons. As a result of these previous experiences, I am aware of the importance of frequent communication among project members and of constructing a realistic research plan, timeline and budget. Finally, I have been surgical PI in 3 RCT on the use of occipital nerve stimulation for Migraine and I have both designed, executed, and participated in a number of other surgical FDA and non-FDA studies in neurosurgery. I am also an active collaborator on DARPA and NIH grants. In summary, I have demonstrated record of successful and productive research projects in an area of high relevance for our population, and my expertise and experience have prepared me to lead the proposed project.
I have been recently appointed as Chief Medical Officer at Medtronic Neuromodulation Operating Unit ·
Contribution to Science[edit]
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[edit]Epilepsy Research I am an active contributor to the field of Epilepsy Surgery. I am the President of the Congress of Neurological Surgeons and also lead a Stereo EEG work group. I have PI and CoI on multiple research protocols and national investigations listed above. I have been either a participant or the largest enroller in studies and lead one of the top ten Epilepsy Surgery programs in the United States.
Coyle A, Riley J, Wu C, Sharan A. From resection to ablation: A review of resective surgical options for temporal lobe epilepsy and rationale for an ablation-based approach. Neurol India. 2017; 65 (Supplement): S71-S77. doi: 10.4103/0028-3886.201662.
Asadi-Pooya AA, Wyeth D, Nei M, Sharan AD, Sperling MR. Postsurgical outcome in patients with auditory auras and drug-resistant epilepsy. Epilepsy Behav. 2017 Jan; 66:49-52. doi: 10.1016/j.yebeh.2016.10.002. Epub 2016 Dec 26.
Asadi-Pooya AA, Stewart GR, Abrams DJ, Sharan A. Prevalence and incidence of drug-resistant mesial temporal lobe epilepsy in the United States. World Neurosurg. 2016 Dec 26. pii: S1878-8750(16)31389-4. doi: 10.1016/j.wneu.2016.12.074. [Epub ahead of print]
Horak PC, Meisenhelter S, Song Y, Testorf ME, Kahana MJ, Viles WD, Bujarski KA, Connolly AC, Robbins AA, Sperling MR, Sharan AD, Worrell GA, Miller LR, Gross RE, Davis KA, Roberts DW, Lega B, Sheth SA, Zaghloul KA, Stein JM, Das SR, Rizzuto DS, Jobst BC. Interictal epileptiform discharges impair word recall in multiple brain areas. Epilepsia. 2016 Dec 9. doi: 10.1111/epi.13633. [Epub ahead of print]
Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS. Direct Electrical Stimulation of the Human Entorhinal Region and Hippocampus Impairs Memory. Neuron. 2016 Dec 7;92(5):983-990. doi: 10.1016/j.neuron.2016.10.062.
Wu C, D'Haese PF, Pallavaram S, Dawant BM, Konrad P, Sharan AD. Variations in Thalamic Anatomy Affect Targeting in Deep Brain Stimulation for Epilepsy. Stereotact Funct Neurosurg. 2016 Nov 16; 94(6):387-396. [Epub ahead of print]
Atsina KB, Sharan AD, Wu C, Evans JJ, Sperling MR, Skidmore CT, Gorniak RJ. Longitudinal Qualitative Characterization of MRI Features After Laser Interstitial Thermal Therapy in Drug-Resistant Epilepsy. AJR Am J Roentgenol. 2016 Sep 22:1-8. [Epub ahead of print]
Robinson LF, He X, Barnett P, Doucet GE, Sperling MR, Sharan A, Tracy JI. The Temporal Instability of Resting State Network Connectivity in Intractable Epilepsy. Hum Brain Mapp. 2016 Sept 15. doi: 10.1002/hbm.23400. [Epub ahead of print]
Asadi-Pooya AA, Nei M, Sharan A, Sperling MR. Patient historical risk factors associated with seizure outcome after surgery for drug-resistant nonlesional temporal lobe epilepsy. World Neurosurg. 2016 Jul;91:205-9. doi: 10.1016/j.wneu.2016.04.022. Epub 2016 Apr 13.
Fuertinger S, Simonyan K, Sperling MR, Sharan AD, Hamzei-Sichani F. High-frequency brain networks undergo modular breakdown during epileptic seizures. Epilepsia. 2016 May 25. doi: 10.1111/epi.13413. [Epub ahead of print]
Asadi-Pooya AA, Nei M, Sharan A, Sperling MR. Auras in patients with temporal lobe epilepsy and mesial temporal sclerosis. J Neurol Sci. 2016 May 15;364:24-6. doi: 10.1016/j.jns.2016.03.006. Epub 2016 Mar 3.
Doucet Ge, He X, Sperling M, Sharan A, Tracy JI. Gray Matter Abnormalities in Temporal Lobe Epilepsy: Relationships with Resting-State Functional Connectivity and Episodic Memory Performance. PLoS One. 2016 May 12;11(5):e0154660. doi: 10.1371/journal.pone.0154660. eCollection 2016.
Osipowicz K, Sperling MR, Sharan AD, Tracy JI. Functional MRI, resting state fMRI, and DTI for predicting verbal fluency outcome following resective surgery for temporal lobe epilepsy. J Neurosurg. 2016 Apr;124(4):929-37. doi: 10.3171/2014.9.JNS131422. Epub 2015 Sep 25.
Kang JY, Wu C, Tracy J, Lorenzo M, Evans J, Nei M, Skidmore C, Mintzer S, Sharan AD, Sperling MR. Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. Epilepsia. 2016 Feb;57(2):325-34. doi: 10.1111/epi.13284. Epub 2015 Dec 24.
Appel S, Sharan AD, Tracy JI, Evans J, Sperling MR. A comparison of occipital and temporal lobe epilepsies. Acta Neurol Scand. 2015 Oct;132(4):284-90. doi: 10.1111/ane.12396. Epub 2015 Mar 24.
Neurostimulation Research
I am also an active contributor to the field of Neuromodulation. I am the President of the national society, North American Neuromodulation Society, which has approximately 1400 members. I am published extensively in the field. Again, we have both lab and clinical research in the areas of occipital stimulation for migraine, sphenopalatine ganglion stimulation for brain blood barrier modulation, the association of pain and sleep, and many technical expertise articles on neuromodulation as well.
Deer T, Pope J, Hayek S, Narouze S, Patil P, Foreman R, Sharan A, Levy R. Neurostimulation for the treatment of axial back pain: a review of mechanisms, techniques, outcomes, and future advances. Neuromodulation. 2014 Oct;17 Suppl 2:52-68. doi: 10.1111/j.1525-1403.2012.00530.x. Review. PMID: 25395117
Falowski S.M., Celii A., Sestokas A.K., Schwartz D.M., Matsumoto C., Sharan A. 2010. Awake vs. Asleep Placement of Spinal Cord Stimulators: A Cohort Analysis of Complications Associated With Placement. Neuromodulation 2011 24(2): E16-E20.
Falowski SM, Sharan A, Reyes BA, Sikkema C, Szot P, Van Bockstaele EJ. An evaluation of neuroplasticity and behavior after deep brain stimulation of the nucleus accumbens in an animal model of depression. Neurosurgery. 2011 Dec;69(6):1281-90. doi: 10.1227/NEU.0b013e3182237346. PMID: 21566538 Ongoing Research Projects (Sharan: Role: Co-I) 07/16/2014-07/15/2018 2.42 calendar months Subcontract/University of Pennsylvania DARPA Memory Enhancement with Modeling, Electrophysiology, and Stimulation (MEMES) The primary objectives of this study are (1) to identify biomarkers of successful memory encoding and retrieval, and (2) to identify brain regions that can be stimulated to enhance memory performance. The secondary objective is to identify biomarkers that can be used to predict cognitive impairment following resection surgery.
(Sharan: Role: Co-I) NIH R01 MH 104606-01 award 08/17/2015 – 05/31/2016 24 calendar months Co-investigator - The Roles of Place and Grid cells in human spatial navigation and memory. Our experiments examine how spatial knowledge is represented by individual cells in the human medial temporal lobe. We test the hypothesis that human navigation is supported by networks of place and grid cells, each of which help encode a person's location in a spatial environment by activating at individual locations and groups of locations, respectively. We probe the functional roles of grid and place cells in human spatial navigation and memory by directly performing single cell neuronal human recording activity of cells from epilepsy patients performing a computer virtual-navigation task. . Completed Research Projects (Silberstein) 09/27/04-12/31/50 .48 calendar months Medtronic, Inc. $148,038 Occipital Nerve Stimulation for the Treatment of Chronic Migraine Headache The major goal of this project is to asses the efficacy of peripheral nerve stimulation in chronic migraine. Role: CO-PI
(Sharan – Role: PI) 12/08/06-12/31/50 .24 calendar months Neuropace $7,250 Responsive Neurostimulator (RNS) System Pivotal Clinical Investigation The major goal of this project is to assess the safety and to demonstrate that the Responsive Neurostimulator (RNS) system is effective as an adjunctive therapy in reducing the frequency of seizures in individuals with partial onset seizures that are refractory to two or more antiepileptic medications.
(Sharan – Role: PI) 05/21/10-05/20/15 .12 calendar months Boston Scientific Neuromodulation Corp. $55,950 The major goal of this project is to assess the therapeutic effectiveness and cost effectiveness of spinal cord stimulation (SCS) compared with reoperation in patients with failed back surgery syndrome (FBSS)
(Sharan – Role: PI) 04/30/10-04/29/13 .12 calendar months Orthofix Spinal Implants $38,480 The major goal of this project is to utilize Trinity Evolution Matrix in conjunction with an inter-body spacer and supplemental anterior fixation and to follow the patients to measure the clinical outcomes and rate of fusion.
(Sharan – Role: PI) 01/17/14-01/16/15 .12 calendar months St. Jude Medical $10,000 Characterization of Frequency-Related Modulation of Neural Activity in Chronic Migraine Patients with Occipital Nerve Implants using PET/CT Imaging. The goal of this project is to verify if frequency-related modulation of neural activity is observed in chronic migraine patients who showed significant beneficial response to either low < 50Hz or high frequency > 50 Hz stimulation using peripheral nerve stimulators (PNS).
(Sharan – Role: PI) 10/04/13-10/3/16 .12 calendar months Medtronic Neuromodulation SubQStim: A Prospective, Randomized, Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Nerve Stimulation $147,670 The major goal of this project is to assess the safety and efficacy of Subcutaneous Nerve Stimulation (SQS) (also known as Peripheral Nerve Stimulation [PNS]) in the reduction of chronic, post-surgical back pain.
(Sharan – Role: PI) 10/10/14-12/31/16 .12 calendar months Saluda Medical Pty. Ltd $71,425 A Prospective, Multicenter, Randomized Double-Blind Crossover Study Examining the Safety and Effectiveness of Using Spinal Cord Stimulation Incorporating Feedback to Treat Patients with Chronic Pain of the Trunk and /or Limbs in an Extended Trial (PANORAMA) The major goal of this project is to is to compare the effectiveness of feedback to non-feedback spinal cord stimulation (SCS) in patients with chronic pain with regard to pain relief and stimulation side effects.
(Sharan – Role: PI) 04/26/06-12/31/50 .12 calendar months Advanced Bionics Corporation $364,699 Precision Spinal Cord Implantable Stimulator System (ONS) The major goal of this project is to evaluate the safety and efficacy of occipital nerve stimulation using the Precision implantable neurostimulation device for migraine.
(Sharan – Role: PI) 05/18/12-05/17/17 .12 calendar months Medtronic through Northwestern University $9,845 SISTER: Spasticity in Stroke-Randomized Study The major goal of this project is to demonstrate that ITB Therapy, compared to BMT, has superior efficacy in the treatment of severe spasticity in adult post-stroke patients with generalized spastic in the lower extremities.
(Sharan – Role: PI) 03/26/14-03/25/16 .12 calendar months Saluda Medical Pty. Ltd A Feasibility Study Evaluating the Saluda Medical SCS System Incorporating Feedback Control using Evoked Compound Action Potentials (ECAP) to Aid in the Accurate Positioning of Paddle Spinal Cord Stimulation (SCS) Leads $22,000 The major goal of this project is to examine the properties of neuron by looking at ECAPs and To examine the feasibility of using ECAPs to aid in the placement of neurostimulation leads.
Occipital
I have been performing occipital nerve stimulation for migraine since 2005 and performing spinal cord stimulation for pain since 1997. I have published numerous time in the field both on scientific mechanisms of action, surgical techniques and clinical outcome. I have personally authored the analysis of the adverse events from the largest clinical trial performed in the space to date. Our lab has worked on the mechanisms of action of this therapy with rodents and with PET scan in humans.
Sharan A, Huh B, Narouze S, Trentman T, Mogilner A, Vaisman J, Ordia J, Deer T, Venkatesan L, Slavin K. Analysis of adverse events in the management of chronic migraine by peripheral nerve stimulation. Neuromodulation. 2015 Jun;18(4):305-12; discussion 312. doi: 10.1111/ner.12243. Epub 2014 Oct 14. PMID: 25313847
DW Dodick, SD Silberstein, KL Reed, TR Deer, AD Sharan, et al. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: Long-term results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia 2015;35(4):344–58.
Hann, S., Sharan, A. Dual occipital and supraorbital nerve stimulation for chronic migraine: a single-center experience, review of literature, and surgical considerations. Neurosurg Focus. 2013 Sep.
Silberstein SD, Dodick DW, Saper J, Huh B, Slavin KV, Sharan A, Reed K, Narouze S, Mogilner A, Goldstein J, Trentman T, Vaisma J, Ordia J, Weber P, Deer T, Levy R, Diaz RL, Washburn SN, Mekhail N. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for themanagement of chronic migraine: results from a randomized, multicenter, double-blinded,controlled study. Cephalalgia. 2012 Dec;32(16):1165-79.
Falowski S. Wang D. Sabesan A. Sharan A. Occipital nerve stimulator systems: review of complications and surgical techniques. Neuromodulation 13(2). 121-5. April 2010
Dodick DW, Silberstein SD, Reed KL, Deer TR, Slavin KV, Huh B, Sharan AD, Narouze S, Mogilner AY, Trentman TL, Ordia J, Vaisman J, Goldstein J, Mekhail N. Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: long-term results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia, 2015 Apr;35(4):344-58. doi: 10.1177/0333102414543331. Epub 2014 Jul 30.
Sweet JA, Mitchell LS, Narouze S, Sharan AD, Falowski SM, Schwalb JM, Machado A, Rosenow JM, Petersen EA, Hayek SM, Arle JE, Pilitsis JG. Occipital Nerve Stimulation for the Treatment of Patients With Medically Refractory Occipital Neuralgia: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline. Neurosurgery. 2015 Sep;77(3):332-41. doi: 10.1227/NEU.0000000000000872.
Clark SW, Wu C, Boorman DW, Chalouhi N, Zanaty M, Oshinsky M, Young WB, Silberstein SD, Sharan AD. Long-Term Pain Reduction Does Not Imply Improved Functional Outcome in Patients Treated With Combined Supraorbital and Occipital Nerve Stimulation for Chronic Migraine. Neuromodulation. 2016 Jul;19(5):507-14. doi: 10.1111/ner.12400. Epub 2016 Feb 10.
Spinal Cord Stimulation Shamji MF, De Vos C, Sharan AD. The Advancing Role of Neuromodulation for the Management of Chronic Treatment-Refractory Pain. Neurosurgery. 21 Feb 2017; 80 (3S): S108-S113.
Epilepsy
He X, Doucet GE, Sperling M, Sharan A, Tracy JI. Reduced thalamocortical functional connectivity in temporal lobe epilepsy. Epilepsia. 2015 Oct;56(10):1571-9. doi: 10.1111/epi.13085. Epub 2015 Jul 21.
Asadi-Pooya AA, Nei M, Sharan A, Sperling MR. Type of preoperative aura may predict postsurgical outcome in patients with temporal lobe epilepsy and mesial temporal sclerosis. Epilepsy Behav. 2015 Sep;50:98-100. doi: 10.1016/j.yebeh.2015.06.041. Epub 2015 Jul 25.
Doucet GE, He X, Sperling M, Sharan A, Tracy JI. Frontal gray matter abnormalities predict seizure outcome in refractory temporal lobe epilepsy patients. Neuroimage Clin. 2015 Sep 18;9:458-66. doi: 10.1016/j.nicl.2015.09.006. eCollection 2015.
Pustina D, Avants B, Sperling M, Gorniak R, He X, Doucet G, Barnett P, Mintzer S, Sharan A, Tracy J. Predicting the laterality of temporal lobe epilepsy from PET, MRI, and DTI: A multimodal study. Neuroimage Clin. 2015 Jul 31;9:20-31. doi: 10.1016/j.nicl.2015.07.010. eCollection 2015.
Wu C, Boorman DW, Gorniak RJ, Farrell CJ, Evans JJ, Sharan AD. The Effects of Anatomic Variations on Stereotactic Laser Amygdalohippocampectomy and a Proposed Protocol for Trajectory Planning. Neurosurgery. 2015 Jun;11 Suppl 2:345-56; discussion 356-7. doi: 10.1227/NEU.0000000000000767.
Doucet GE, Rider, R, Taylor, N, Skidmore C, Sharan A, Sperling M, Tracy JI. Presurgery resting-state local graph-theory measures predict neurocognitive outcomes after brain surgery in temporal lobe epilepsy. Epilepsia, 2015 Apr;56(4):517-26. doi: 10.1111/epi.12936. Epub 2015 Feb 23.
Salanova V, Witt T, Worth R, Henry TR, Gross RE, Nazzaro JM, Labar D, Sperling MR, Sharan A, Sandok E, Handforth A, Stern JM, Chung S, Henderson JM, French J, Baltuch G, Rosenfeld WE, Garcia P, Barbaro NM, Fountain NB, Elias WJ, Goodman RR, Pollard JR, Tröster AI, Irwin CP, Lambrecht K, Graves N, Fisher R. Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy. SANTE Study Group. Neurology. 2015 Mar 10;84(10):1017-25. doi: 10.1212/WNL.0000000000001334. Epub 2015 Feb 6.
Doucet GE, Sharan A, Pustina D, Skidmore C, Sperling MR, Tracy JI.. Early and Late Age of Seizure Onset have a Differential Impact on Brain Resting-State Organization in Temporal Lobe Epilepsy. Brain Topography, 2015 Jan;28(1):113-26. doi: 10.1007/s10548-014-0366-6. Epub 2014 Jun 1.
Shetty A, Wu C, Fernald B, Mehta A, Sperling M, Sharan AD. Relationship between Seizure Outcomes and MTLE Ablation Volumetrics for Stereotactic Laser Ablation. Stereotact Funct Neurosurg 2014; 92 (suppl 1): 1-75
Burke JF, Sharan AD, Sperling MR, Ramayya AG, Evans JJ, Healey MK, Beck EN, Davis KA, Lucas TH 2nd, Kahana MJ. Theta and High-Frequency Activity Mark Spontaneous Recall of Episodic Memories. Journal of Neuroscience. 2014 Aug 20;34(34):11355-65. doi: 10.1523/JNEUROSCI.2654-13.2014.
Wu C, LaRiviere MJ, Laxpati N, Evans JJ, Gross RE, Sharan AD. Extraventricular Long-Axis Cannulation of the Hippocampus: Technical Considerations. Neurosurgery. 2014 Jun;10 Suppl 2:325-32; discussion 332-3. doi: 10.1227/NEU.0000000000000320.
Misra A, Burke JF, Ramayya AG, Jacobs J, Sperling MR, Moxon KA, Kahana MJ, Evans JJ, Sharan AD. Methods for implantation of micro-wire bundles and optimization of single/multiunit recordings from human mesial temporal lobe. Journal of Neural Engineering, 2014 Apr;11(2):026013. doi: 10.1088/1741-2560/11/2/026013. Epub 2014 Mar 10.
Rodriguez Merzagora, A.,Coffey, T. J.,Sperling, M. R., Sharan, A.,Litt, B.,Baltuch, G.,Jacobs, J. Repeated stimuli elicit diminished high-gamma electrocorticographic responses. Neuroimage. 2014 Jan 15;85 Pt 2:844-52. doi: 10.1016/j.neuroimage.2013.07.006. Epub 2013 Jul 16.
Burke, J. F.,Long, N. M.,Zaghloul, K. A.,Sharan, A. D.,Sperling, M. R.,Kahana, M. J. Human intracranial high-frequency activity maps episodic memory formation in space and time. Neuroimage. 2014 Jan 15;85 Pt 2:834-43. doi: 10.1016/j.neuroimage.2013.06.067. Epub 2013 Jul 1.
Gross RE, Willie JT, Sharan AD, Sperling M, Shih JJ, Wharen RE, Tatum W, Popli G, Couture DE, Laxton AW, Labiner DM, Weinand ME, Marsh WR, Cascino G, Worrell GA, Wilfong AA, Curry D. Stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy: collective experience from 7 single-center, prospective, investigator-initiated studies. Neurosurgery 2014, 61 Suppl 1:192.
Wu C, Gorniak R, Mehdi M, Sperling M, Sharan AD. Methodology for critical evaluation of laser placement in stereotactic laser ablation for mesial temporal lobe epilepsy: a pilot study. Neurosurgery 2014, 61 Suppl 1:223.
Morton, N. W.,Kahana, M. J.,Rosenberg, E. A.,Baltuch, G. H.,Litt, B.,Sharan, A. D.,Sperling, M. R.,Polyn, S. M. Category-specific neural oscillations predict recall organization during memory search. Cereb. Cortex. 2013 Oct;23(10):2407-22. doi: 10.1093/cercor/bhs229. Epub 2012 Aug 8.
Doucet G, Osipowicz K, Sharan A, Sperling MR, Tracy JI. Extratemporal functional connectivity impairments at rest are related to memory performance in mesial temporal epilepsy. Hum Brain Mapp. 2013 Sep;34(9):2202-16. doi: 10.1002/hbm.22059. Epub 2012 Apr 16.
Jacobs, J.,Weidemann, C. T.,Miller, J. F.,Solway, A.,Burke, J. F.,Wei, X. X.,Suthana, N.,Sperling, M. R., Sharan, A. D.,Fried, I.,Kahana, M. J. Direct recordings of grid-like neuronal activity in human spatial navigation. Nat. Neurosci.. 2013 Sep;16(9):1188-90. doi: 10.1038/nn.3466. Epub 2013 Aug 4.
Tracy, J. I.,Hernandez, R. N.,Mayekar, S.,Osipowicz, K.,Corbett, B.,Pascua, M.,Sperling, M. R., Sharan, A. D. The functional anatomy of non-verbal (pitch memory) function in left and right anterior temporal lobectomy patients. Clin Neurol Neurosurg. 2013 Jul;115(7):934-43. doi: 10.1016/j.clineuro.2012.09.019. Epub 2012 Sep 30.
Van Gerven MA, Maris E, Sperling M, Sharan A, Litt B, Anderson C, Baltuch G, Jacobs J Decoding the memorization of individual stimuli with direct human brain recordings. Neuroimage. 2013 Apr 15;70:223-32. doi: 10.1016/j.neuroimage.2012.12.059. Epub 2013 Jan 5.
Tracy, J. I., Osipowicz, K., Spechler, P., Sharan, A., Skidmore, C., Doucet, G. and Sperling, M. R. Functional connectivity evidence of cortico–cortico inhibition in temporal lobe epilepsy. Neuromodulation. 2013 Jan-Feb;16(1):10-24; discussion 24. doi: 10.1111/j.1525-1403.2012.00501.x. Epub 2012 Sep 4.
Burke, J. F.,Zaghloul, K. A.,Jacobs, J.,Williams, R. B.,Sperling, M. R.,Sharan, A. D.,Kahana, M. J. Synchronous and asynchronous theta and gamma activity during episodic memory formation. J Neurosci. 2013 Jan 2;33(1):292-304. doi: 10.1523/JNEUROSCI.2057-12.2013.
Wu C, Evans JJ, Skidmore C, Sperling MR, Sharan AD. Impedance Variations over Time for a Closed-Loop Neurostimulation Device: Early Experience with Chronically Implanted Electrodes. Neuromodulation. 2013 Jan;16(1):46-50. doi: 10.1111/j.1525-1403.2012.00529.x. Epub 2012 Nov 8.
Wu C, Sharan AD. Neurostimulation for the treatment of epilepsy: a review of current surgical interventions. Neuromodulation. 2013 Jan;16(1):10-24. doi: 10.1111/j.1525-1403.2012.00501.x. Epub 2012 Sep 4.
Doucet, G.,Osipowicz, K.,Sharan, A.,Sperling, M.,Tracy, J. Hippocampal functional connectivity patterns during spatial working memory differ in right versus left temporal lobe epilepsy. Brain Connect. 2013;3(4):398-406. doi: 10.1089/brain.2013.0158.
Wu C, Sperling MR, Falowski SM, Chitale AV, Werner-Wasik M, Evans JJ, Andrews DW, Sharan AD. Radiosurgery for the treatment of dominant hemisphere periventricular heterotopia and intractable epilepsy in a series of three patients. Epilepsy & Behavior: Case Reports, 2012 Nov 7;1:1-6. doi: 10.1016/j.ebcr.2012.10.004. eCollection 2013.
Tracy JI, Nick Hernandez R, Mayekar S, Osipowicz K, Corbett B, Pascua M, Sperling MR, Sharan AD. The functional anatomy of non-verbal (pitch memory) function in left and right anterior temporal lobectomy patients. Clin Neurol Neurosurg. 2012 Sep 29. doi:pii: S0303-8467(12)00497-0. 10.1016/j.clineuro.2012.09.019
Manning J, Sperling M, Sharan A, Rosenberg E, Kahana M. J Spontaneously reactivated patterns in frontal and temporal lobe predict semantic clustering during memory search. Neurosci. 2012 Jun 27;32(26):8871-8. doi: 10.1523/JNEUROSCI.5321-11.2012.
LoPinto-Khoury C, Sperling MR, Skidmore C, Nei M, Evans J, Sharan A, Mintzer S. Surgical outcome in PET-positive, MRI-negative patients with temporal lobe epilepsy. Epilepsia. 2012 Feb;53(2):342-8