User:Matthomas118/NOREPINEPHRINE TRANSPORTER

Norepinephrine Transporter (NET)

Brief introduction

Function

• norepinenphrine

NET Gene

NET SNPs

• briefly- what SNPs are and why nonsynonymous SNPs are areas of interest for researchers
• evidence suggesting relationship between SNPs and disorders such as ADHD and depression
  • only established relationship is between missense (nonsynonymous) polymorphism Ala457Pro and orthostatic intolerance (source: Tellioglu) [see below for OI]
• table of some SNPs (GoogleBooks- Reith)

Clinical Significance

• research with ADHD and depression etc. has yielded evidence but nothing has been proven yet (source: Tellioglu)

Orthostatic Intolerance

• SNP Ala457Pro

Therapeutic Potential

Norepinephrine reuptake inhibitor

• briefly, what it is and how it affects the NET, then below name medications for each condition

Further Research

• Understanding mental illness

References

1. Tellioglu T, Robertson D (November 2001). "Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications". Expert Rev Mol Med 2001: 1–10. doi:10.1017/S1462399401003878. PMID 14987367.
2. Haenisch B, Bonisch H (March 2011). "Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters". Pharmacology & Therapeutics 2011: 129-3. doi:10.1016/j.pharmthera.2010.12.002.
3. Zhou J (December 2004). "Norepinephrine transporter inhibitors and their therapeutic potential". Drugs Future 2004: 29-12. PMC 1518795.
4. Oaks AW, Sidhu A (April 2011). "Synuclein modulation of monoamine transporters". FEBS Letters 2011: 585-7. doi:10.1016/j.febslet.2011.03.009

Division of Workload

We have decided to divide the research into topics then meet whenever possible to create a cohesive Wikipedia page as a group.