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TMEM202
[edit]Genetic Overview
[edit]Transmembrane gene 202 (Homo sapiens, TMEM202), encodes the protein TMEM202 and is a member of the Claudin2 superfamily[1][2]. Human paralogs include LIMP2, GSG1, CLDND2, NKG7[3]. The function of TMEM202 is still largely unknown, but other Claudin2 superfamily proteins plays important roles in paracellualar transport by contributing to the structure of gap junctions[4]. Claudin proteins often form protein-protein interactions in epithelial and endothelial tissue, contributing to the scaffolding of the tight junction.
TMEM202 Gene
[edit]
The TMEM202 gene spans 10,063 nucleotides on chromosome 15 located at 15q23-q24.1 and on the forward strand.[2]
TMEM202 mRNA Transcript
[edit]The mRNA transcript of TMEM202, transcript variant 1 spans 1,318 nucleotides.[5] TMEM202 demonstrates low expression restricted to the testis.[6]
TMEM202 Protein
[edit]TMEM202 is found in cell membranes and is classified as a multi-pass protein as it consists of four transmembrane domains with helical structure and one disordered region.[2][7]
Evolution of TMEM202
[edit]Orthologs of TMEM202
[edit]- ^ "Gene: TMEM202 (ENSG00000187806) - Summary - Homo_sapiens - Ensembl genome browser 113". useast.ensembl.org. Retrieved 2024-10-21.
- ^ a b c "TMEM202 transmembrane protein 202 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-21.
- ^ "TCDB » SEARCH". www.tcdb.org. Retrieved 2024-10-21.
- ^ Heiskala, M.; Peterson, P. A.; Yang, Y. (2001-02). "The roles of claudin superfamily proteins in paracellular transport". Traffic (Copenhagen, Denmark). 2 (2): 93–98. doi:10.1034/j.1600-0854.2001.020203.x. ISSN 1398-9219. PMID 11247307.
{{cite journal}}: Check date values in:|date=(help) - ^ "Homo sapiens transmembrane protein 202 (TMEM202), transcript variant 1, mRNA". 2024-08-03.
{{cite journal}}: Cite journal requires|journal=(help) - ^ "AceView: Gene:TMEM202, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-10-21.
- ^ "UniProt". www.uniprot.org. Retrieved 2024-10-21.