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Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
| Allele name | Btbd12tm1(EUCOMM)Wtsi |
| Program | EUCOMM |
| Critical exon | This is exon 3 of 15 (Transcript ENSMUST0000040790) Ablatation of the floxed exon causes a frameshift mutation |
 |
| All available Targeted Sanger ES Cells |
|
| ES Cell clone used for phenotyping |
| ES Cell Name: EPD0027_2_A08 |
ES Cell Strain: C57Bl/6N |
ES Cell Line: JM8.N4 |
|
Sanger Mice[edit]
| Genetic Background | C57BL/6NTac/Den;C57BL/6-Tyr;C57BL/6N |
| Genotyping information | Primers and conditions here... |
| Register interest at ... | EMMA |
Expression[edit]
| Adult Expression |
Strong expression observed in adult brain and male reproductive organsSample expression dataSample expression data
|
| Age |
Profile Available |
Piccies |
|---|
| E10.5 |
No |
whole pic |
| E14.5 |
Yes |
A sample phenotype expression mount
|
| E18.5 |
No |
|
| Adult |
Yes |
SC
PNS
skin
NE
oe
eye
bat
sm
bone
Cartilage
vs
wat
Trachea
oesophagus
lung
thymus
stomach
si
li
colon
pp
spleen
mln
pancreas
ag
Kidney
us
mg
ovaries
oviduct
uterus
testis
prostate
vas
|
|
Phenotype[edit]
| Phenotype |
| Phenotyping pipeline | link to pipeline |
| Headline observations |
Male and female homozygotes show reduced viability and are infertile.
Female homs show decreased body weight and decreased nose-to-tail length
|
| Progeny from het x het intercross (number of progeny and ratio) |
| WT | HET | HOM |
| 119 (0.33) | 203 (0.57) | 37 (0.1) |
|
| This is the big table of breeding stats |
|
|
| Reduced nose-tail length in females, reduced body weight in females |
  |
|
Cool picture of shrunk testes
|
A sample phenotype image
|
