User:Mohammed.hassan90/Amino acid activation

In particular, leucin NK treatment of IL-18 activated cells triggers mTORC1 metabolic sensor, which indicates that mTORC1 causes amino acid-driven activation due to a high expression in amino acid transporters.

The Inhibition of CD98/LAT1 amino acid transporters abroad mTORC1 activation driven by leucine, decreased the activity of the NK cell-effector.^[1]

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^ Almutairi, Saeedah Musaed; Ali, Alaa Kassim; He, William; Yang, Doo-Seok; Ghorbani, Peyman; Wang, Lisheng; Fullerton, Morgan D.; Lee, Seung-Hwan (2019-03-XX). "Interleukin-18 up-regulates amino acid transporters and facilitates amino acid–induced mTORC1 activation in natural killer cells". Journal of Biological Chemistry. 294 (12): 4644–4655. doi:10.1074/jbc.RA118.005892. PMC 6433059. PMID 30696773. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

[1] Almutairi, Saeedah Musaed; Ali, Alaa Kassim; He, William; Yang, Doo-Seok; Ghorbani, Peyman; Wang, Lisheng; Fullerton, Morgan D.; Lee, Seung-Hwan (2019-03-XX). "Interleukin-18 up-regulates amino acid transporters and facilitates amino acid–induced mTORC1 activation in natural killer cells". Journal of Biological Chemistry. 294 (12): 4644–4655. doi:10.1074/jbc.RA118.005892. PMC 6433059. PMID 30696773. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

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