User:Monoclonalantibodies/Immunosuppressive drug

Glucocorticoids suppress cell-mediated immunity. They act by inhibiting gene expression of cytokines including Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and TNF-alpha by binding to corticosteroid response elements on DNA.^[1] This decrease in cytokine production reduces T cell proliferation. With decreased T cell proliferation there is decreased production of IL-2. This further decreases the proliferation of T cells. ^[2],^[3]

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^ Jennings, Douglas L (2020). Pharmacotherapy : A Pathophysiologic Approach. Joseph T. DiPiro, Gary C. Yee, L. Michael Posey, Stuart T. Haines, Thomas D. Nolin, Vicki L. Ellingrod (11th ed.). United States of America: McGraw Hill Medical. ISBN 978-1-260-11681-6.{{cite book}}: CS1 maint: date and year (link)
^ Coutinho, Agnes E.; Chapman, Karen E. (2011-03). "The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights". Molecular and Cellular Endocrinology. 335 (1): 2–13. doi:10.1016/j.mce.2010.04.005. PMC 3047790. PMID 20398732. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)
^ Schimmer, Bernard P; Funder, John W (2018). Shanahan, James F; Lebowitz, Harriet (eds.). Goodman & Gilman's the pharmacological basis of therapeutics (13th ed.). New York: McGraw Hill Medical. ISBN 978-1-259-58473-2.

[1] Jennings, Douglas L (2020). Pharmacotherapy : A Pathophysiologic Approach. Joseph T. DiPiro, Gary C. Yee, L. Michael Posey, Stuart T. Haines, Thomas D. Nolin, Vicki L. Ellingrod (11th ed.). United States of America: McGraw Hill Medical. ISBN 978-1-260-11681-6.{{cite book}}: CS1 maint: date and year (link)

[2] Coutinho, Agnes E.; Chapman, Karen E. (2011-03). "The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights". Molecular and Cellular Endocrinology. 335 (1): 2–13. doi:10.1016/j.mce.2010.04.005. PMC 3047790. PMID 20398732. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)

[3] Schimmer, Bernard P; Funder, John W (2018). Shanahan, James F; Lebowitz, Harriet (eds.). Goodman & Gilman's the pharmacological basis of therapeutics (13th ed.). New York: McGraw Hill Medical. ISBN 978-1-259-58473-2.

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