User:Mr. Ibrahem/Abacavir/lamivudine

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Mr. Ibrahem/Abacavir/lamivudine
Combination of
AbacavirNucleotide analogue reverse transcriptase inhibitor
LamivudineNucleotide analogue reverse transcriptase inhibitor
Clinical data
Trade namesKivexa, Epzicom, others
MedlinePlusa696011
Routes of
administration		by mouth
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
 ☒NcheckY (what is this?)  (verify)

Abacavir/lamivudine, sold under the brand name Kivexa among others, is a fixed-dose combination medication used to treat HIV/AIDS.[2] It contains abacavir and lamivudine.[2] It is generally recommended for use with other antiretrovirals.[2] It is commonly used as part of the preferred treatment in children.[3] It is taken by mouth as a tablet.[2]

Common side effects include trouble sleeping, headache, depression, feeling tired, nausea, rash, and fever.[2] Serious side effects may include high blood lactate levels, allergic reactions, and enlargement of the liver.[2] It is not recommended in people with a specific gene known as HLA-B*5701.[2] Safety in pregnancy has not been well studied but it appears to be okay.[4] Lamivudine and abacavir are both nucleoside reverse transcriptase inhibitors (NRTI).[2]

Abacavir/lamivudine was approved for medical use in the United States in 2004.[2] It is on the World Health Organization's List of Essential Medicines.[5] Thewholesale cost in the developing world is about US$14.19 to $16.74 per month as of 2014.[6] As of 2015, the cost for a typical month of medication in the United States is more than $200.[7]

References[edit]

  1. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 7 August 2020. Retrieved 20 September 2020.
  2. ^ a b c d e f g h i "Abacavir and Lamivudine Tablets". Teva Pharmaceuticals USA. Archived from the original on 6 February 2017. Retrieved 28 November 2016.
  3. ^ World Health Organization (2015). The selection and use of essential medicines. Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. pp. 45–46. hdl:10665/189763. ISBN 9789241209946. ISSN 0512-3054. WHO technical report series;994.
  4. ^ "Abacavir / lamivudine (Epzicom) Use During Pregnancy". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 4 December 2016.
  5. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ^ "Abacavir + Lamivudine". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 28 November 2016.
  7. ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 59. ISBN 9781284057560.
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