User:Mr. Ibrahem/Alitretinoin

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Mr. Ibrahem/Alitretinoin
Clinical data
Trade namesPanretin, Toctino, other
Other names9-cis-retinoic acid
AHFS/Drugs.comMonograph
MedlinePlusa601012
License data
Routes of
administration		Topical, by mouth
Drug classRetinoid[1]
Legal status
Legal status
Pharmacokinetic data
Protein bindingHighly bound, no exact figure available[2]
MetabolismLiver (CYP3A4-mediated oxidation, also isomerised to tretinoin)[2]
Elimination half-life2-10 hours[2]
ExcretionUrine (64%), faeces (30%)[2]
Identifiers
  • (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-
    1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid
Chemical and physical data
FormulaC20H28O2
Molar mass300.442 g·mol−1
3D model (JSmol)
  • O=C(O)\C=C(\C=C\C=C(/C=C/C1=C(/CCCC1(C)C)C)C)C
  • InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ checkY
  • Key:SHGAZHPCJJPHSC-ZVCIMWCZSA-N checkY
  (verify)

Alitretinoin, sold under the brand name Panretin among others, is a medication used to treat Kaposi’s sarcoma due to AIDS and eczema of the hands.[3][4] It is only used to treat disease involving the skin.[3] It is applied to the skin or take by mouth.[1]

Common side effects include when applied to the skin include itchiness, skin peeling, and rash.[3] Common side effects when taken by mouth include hair loss, low red blood cells, tiredness, high blood pressure, high cholesterol, and ringing in the ears.[4] Other side effects may include sunburns.[3] Use in pregnancy may harm the baby.[3] It is a retinoid.[1]

Alitretinoin was approved for medical use in the United States in 1999.[3] While it was approved for use in Europe in 2000, this has subsequently been withdrawn.[5] It is available as a generic medication.[4] In the United Kingdom a month of pills costs the NHS about £500 as of 2021.[4] In the United States a 60 gram tube costs about 5,600 USD as of 2022.[6]

References

  1. ^ a b c "DailyMed - panretin- alitretinoin gel". dailymed.nlm.nih.gov. Archived from the original on 15 January 2021. Retrieved 14 January 2022.
  2. ^ a b c d "Toctino 10mg and 30mg soft capsules - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Stiefel. 30 August 2013. Archived from the original on 23 May 2018. Retrieved 1 February 2014.
  3. ^ a b c d e f g h "Alitretinoin Monograph for Professionals". Drugs.com. Archived from the original on 19 August 2021. Retrieved 14 January 2022.
  4. ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1306. ISBN 978-0857114105.
  5. ^ "Panretin". Archived from the original on 26 June 2021. Retrieved 14 January 2022.
  6. ^ "Alitretinoin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 14 January 2022.
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