User:Mr. Ibrahem/Belinostat

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This is the current revision of this page, as edited by Mr. Ibrahem (talk | contribs) at 23:40, 18 February 2024 (from https://mdwiki.org/wiki/Belinostat). The present address (URL) is a permanent link to this version.

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Mr. Ibrahem/Belinostat
Clinical data
Trade namesBeleodaq
Other namesPXD101
AHFS/Drugs.comMonograph
Routes of
administration		Intravenous (IV)
Drug classHistone deacetylase inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability100% (IV)
Protein binding92.9–95.8%[2]
MetabolismUGT1A1
ExcretionUrine
Identifiers
  • (2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
Chemical and physical data
FormulaC15H14N2O4S
Molar mass318.35 g·mol−1
3D model (JSmol)
  • O=S(=O)(Nc1ccccc1)c2cc(\C=C\C(=O)NO)ccc2
  • InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+ checkY
  • Key:NCNRHFGMJRPRSK-MDZDMXLPSA-N checkY

Belinostat, sold under the brand name Beleodaq, is a medication used to treat peripheral T-cell lymphoma (PTCL).[1] It is used when other treatments have failed.[3] Regarding if it improves life expectancy is unclear as of 2020.[3] It is given by injection into a vein.[1]

Common side effects include nausea, tiredness, fever, and low red blood cells.[3] Other side effects may include low platelets, low white blood cells, infection, liver problems, and tumor lysis syndrome.[3] Use in pregnancy may harm the baby.[3] It is a histone deacetylase inhibitor.[1]

Belinostat was approved for medical use in the United States in 2014.[3] It was given an orphan designation in Europe in 2012.[4] In the United States a vial of 500 mg costs about 2,100 USD as of 2022.[5]

References[edit]

  1. ^ a b c d e "Belinostat Monograph for Professionals". Drugs.com. Retrieved 8 January 2022.
  2. ^ "Beleodaq (belinostat) For Injection, For Intravenous Administration. Full Prescribing Information" (PDF). Spectrum Pharmaceuticals, Inc. Irvine, CA 92618. Archived from the original (PDF) on 4 March 2016. Retrieved 21 November 2015.
  3. ^ a b c d e f g "DailyMed - BELEODAQ- belinostat injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 25 March 2021. Retrieved 8 January 2022.
  4. ^ "EU/3/12/1055: Orphan designation for the treatment of peripheral T-cell lymphoma (nodal, other extranodal and leukaemic/disseminated)". Archived from the original on 11 January 2022. Retrieved 8 January 2022.
  5. ^ "Belinostat Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 January 2022.
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