User:Mr. Ibrahem/Crizanlizumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized |
| Target | selectin P |
| Clinical data | |
| Trade names | Adakveo, Ryverna, others |
| Other names | SEG101, SelG1, crizanlizumab-tmca |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a620010 |
| License data |
|
| Pregnancy category | |
| Routes of administration | Intravenous |
| Drug class | P-selectin inhibitor[3] |
| Legal status | |
| Legal status | |
| Chemical and physical data | |
| Formula | C6458H9948N1712O2050S58 |
| Molar mass | 146232.04 g·mol−1 |
Crizanlizumab, sold under the brand name Adakveo among others, is a medication used to treat sickle cell disease.[4] Specifically it is used to reduce the frequency of vaso-occlusive crisis in people over 15 years old.[4] It is given by injection into vein.[4]
Common side effects include joint pain, nausea, fever, and abdominal pain.[3] Other side effects may include infusion reactions.[4] Use in pregnancy may harm the baby.[4] It is a monoclonal antibody that binds to and blocks P-selectin, decreasing the attaching of cells to the inside of blood vessels.[3]
Crizanlizumab was approved for medical use in the United States in 2019 and Europe in 2020.[4][3] In the United Kingdom 100 mg costs the NHS about £1,000 as of 2021.[5] This amount in the United States is about 2,400 USD.[6]
References[edit]
- ^ a b "AusPAR: Crizanlizumab". Therapeutic Goods Administration (TGA). 24 August 2021. Archived from the original on 4 September 2021. Retrieved 4 September 2021.
- ^ a b "Adakveo". Therapeutic Goods Administration (TGA). 16 April 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.
- ^ a b c d e "Adakveo". Archived from the original on 14 November 2021. Retrieved 7 January 2022.
- ^ a b c d e f g h "DailyMed - ADAKVEO- crizanlizumab injection". dailymed.nlm.nih.gov. Archived from the original on 8 May 2021. Retrieved 7 January 2022.
- ^ "Crizanlizumab". SPS - Specialist Pharmacy Service. 6 December 2016. Archived from the original on 11 January 2022. Retrieved 7 January 2022.
- ^ "Crizanlizumab Prices and Crizanlizumab Coupons - GoodRx". GoodRx. Retrieved 7 January 2022.