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User:Mr. Ibrahem/Degarelix

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This is the current revision of this page, as edited by Mr. Ibrahem (talk | contribs) at 09:10, 13 February 2024 (from https://mdwiki.org/wiki/Degarelix). The present address (URL) is a permanent link to this version.

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Mr. Ibrahem/Degarelix
Clinical data
Trade namesFirmagon, others
Other namesFE-200486
AHFS/Drugs.comMonograph
MedlinePlusa609022
License data
Pregnancy
category
Routes of
administration		Subcutaneous injection
Drug classGnRH analogue; GnRH antagonist; Antigonadotropin
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)[2]
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability30–40%
Protein binding~90%
MetabolismSubject to common peptidic degradation during passage through the hepato-biliary system; not a substrate for the human CYP450 system
Elimination half-life23–61 days
ExcretionFeces: 70–80%
Urine: 20–30%
Chemical and physical data
FormulaC82H103ClN18O16
Molar mass1632.29 g·mol−1
3D model (JSmol)
  • C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccc(cc2)NC(=O)N)NC(=O)[C@H](Cc3ccc(cc3)NC(=O)[C@@H]4CC(=O)NC(=O)N4)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc5cccnc5)NC(=O)[C@@H](Cc6ccc(cc6)Cl)NC(=O)[C@@H](Cc7ccc8ccccc8c7)NC(=O)C
  • InChI=1S/C82H103ClN18O16/c1-45(2)35-60(72(107)92-59(16-9-10-33-87-46(3)4)80(115)101-34-12-17-68(101)79(114)88-47(5)70(84)105)93-74(109)63(38-51-23-30-58(31-24-51)91-81(85)116)95-76(111)64(39-50-21-28-57(29-22-50)90-71(106)66-42-69(104)100-82(117)99-66)97-78(113)67(44-102)98-77(112)65(41-53-13-11-32-86-43-53)96-75(110)62(37-49-19-26-56(83)27-20-49)94-73(108)61(89-48(6)103)40-52-18-25-54-14-7-8-15-55(54)36-52/h7-8,11,13-15,18-32,36,43,45-47,59-68,87,102H,9-10,12,16-17,33-35,37-42,44H2,1-6H3,(H2,84,105)(H,88,114)(H,89,103)(H,90,106)(H,92,107)(H,93,109)(H,94,108)(H,95,111)(H,96,110)(H,97,113)(H,98,112)(H3,85,91,116)(H2,99,100,104,117)/t47-,59+,60+,61-,62-,63-,64+,65-,66+,67+,68+/m1/s1 ☒N
  • Key:MEUCPCLKGZSHTA-XYAYPHGZSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Degarelix, sold under the brand name Firmagon among others, is a medication used to treat prostate cancer.[3][4] Specifically it is used for advanced disease that is hormone dependent.[5] It is given by injection under the skin.[5]

Common side effects include pain at the site of injection, hot flushes, and liver problems.[3] Other side effects may include anaphylaxis, QT prolongation, and infertility.[3] Use in pregnancy may harm the baby.[3] It is a GnRH receptor antagonist and works by reducing the amount of testosterone in the body.[3][6]

Degarelix was approved for medical use in the United States in 2008 and Europe in 2009.[4][6] In the United Kingdom 80 mg cost the NHS about £130 as of 2021.[5] In the United States this amount costs about 520 USD.[7]

References[edit]

  1. ^ a b c "Degarelix (Firmagon) Use During Pregnancy". Drugs.com. 3 February 2020. Archived from the original on 26 February 2020. Retrieved 25 February 2020.
  2. ^ "Firmagon 120mg Injection - Summary of Product Characteristics (SmPC)". (emc). 15 January 2020. Archived from the original on 26 February 2020. Retrieved 25 February 2020.
  3. ^ a b c d e f g "Firmagon- degarelix kit". DailyMed. 18 September 2019. Archived from the original on 12 August 2020. Retrieved 26 February 2020.
  4. ^ a b "Degarelix Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 22 December 2021.
  5. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 992. ISBN 978-0857114105.
  6. ^ a b "Firmagon". Archived from the original on 26 February 2020. Retrieved 22 December 2021.
  7. ^ "Firmagon Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 April 2021. Retrieved 22 December 2021.
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