User:Mr. Ibrahem/Dicloxacillin
Clinical data | |
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Pronunciation | dye klox' a sil' in[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a685017 |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Antibiotic (penicillin)[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 60 to 80% |
Protein binding | 98% |
Metabolism | Liver |
Elimination half-life | 0.7 hours |
Excretion | Kidney and biliary |
Identifiers | |
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Chemical and physical data | |
Formula | C19H17Cl2N3O5S |
Molar mass | 470.32 g·mol−1 |
3D model (JSmol) | |
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Dicloxacillin is an antibiotics used to treat Staphylococcal infections.[2] This may include cellulitis, osteomyelitis, and pneumonia.[3] While it is effective in penicillinase resistant disease it not effective for MRSA.[2] It is taken by mouth.[2]
Common side effects include nausea, diarrhea, rash, and allergic reactions.[1] Other side effects may include anaphylaxis, Clostridium difficile diarrhea and low white blood cells.[1] Use in pregnancy appears to be relatively safe, but has not been well studied.[4] It is a β-lactam antibiotic and penicillin.[1] It works by interfering with the bacterial cell wall.[1]
Dicloxacillin was patented in 1961 and approved for medical use in 1968.[5] It is available as a generic medication.[1] In the United States 40 pills of 500 mg costs about 30 USD as of 2021.[6]
References[edit]
- ^ a b c d e f g h i "Dicloxacillin". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 28 August 2021. Retrieved 24 December 2021.
- ^ a b c d "Dicloxacillin Monograph for Professionals". Drugs.com. Archived from the original on 20 January 2021. Retrieved 24 December 2021.
- ^ "289107 DICLOXACILLIN MYLAN 500 dicloxacillin (as sodium) 500 mg capsule bottle". Archived from the original on 11 January 2022. Retrieved 24 December 2021.
- ^ "Dicloxacillin Use During Pregnancy". Drugs.com. Archived from the original on 3 December 2020. Retrieved 24 December 2021.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 491. ISBN 9783527607495. Archived from the original on 2021-05-20. Retrieved 2020-12-01.
- ^ "Dicloxacillin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 February 2017. Retrieved 24 December 2021.