User:Mr. Ibrahem/Floxuridine

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This is the current revision of this page, as edited by Mr. Ibrahem (talk | contribs) at 00:11, 22 March 2024 (from https://mdwiki.org/wiki/Floxuridine). The present address (URL) is a permanent link to this version.

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Mr. Ibrahem/Floxuridine
Clinical data
Other names5-fluorodeoxyuridine
AHFS/Drugs.comMonograph
MedlinePlusa682006
Routes of
administration		Intra-arterial
Drug classAntimetabolite[1]
Identifiers
  • 5-Fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione
Chemical and physical data
FormulaC9H11FN2O5
Molar mass246.194 g·mol−1
3D model (JSmol)
Melting point150.5 °C (302.9 °F)
  • FC=1C(=O)NC(=O)N(C=1)[C@@H]2O[C@@H]([C@@H](O)C2)CO
  • InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 checkY
  • Key:ODKNJVUHOIMIIZ-RRKCRQDMSA-N checkY
  (verify)

Floxuridine is a medication used to treat liver cancer and gastrointestinal adenocarcinoma or colorectal cancer that has spread to the liver.[1][2] It is given by gradual injection into an artery supplying the cancer.[1]

Common side effects include bone marrow suppression, tiredness, headache, dizziness, trouble sleeping, numbness, abdominal pain, constipation, diarrhea, heart burn, nausea, mouth inflammation, and rash.[2] Other side effects may include liver problems.[2] Due to the severity of side effects people are generally admitted to hospital during initial treatment.[1] It is an antimetabolite, specifically a pyrimidine analog.[1]

Floxuridine was approved for medical use in the United States in 1970.[1] It is available as a generic medication.[2] In the United States 500 mg did costs about 130 USD; though the only manufacturer stopped making the medication in 2019.[3][4]

References[edit]

  1. ^ a b c d e f g "Floxuridine Monograph for Professionals". Drugs.com. Archived from the original on 16 August 2019. Retrieved 11 December 2021.
  2. ^ a b c d e f "Floxuridine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 December 2021. Retrieved 11 December 2021.
  3. ^ "Floxuridine Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 17 April 2021. Retrieved 11 December 2021.
  4. ^ "Drug Shortage Detail: Floxuridine Injection". www.ashp.org. Archived from the original on 18 September 2021. Retrieved 11 December 2021.
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