User:Mr. Ibrahem/Ganaxolone

Mr. Ibrahem/Ganaxolone
Clinical data
Trade names	Ztalmy
Other names	GNX; CCD-1042; 3β-Methyl-5α-pregnan-3α-ol-20-one; 3α-Hydroxy-3β-methyl-5α-pregnan-20-one
AHFS/Drugs.com	Monograph
License data	US DailyMed: Ganaxolone;
Routes of; administration	By mouth
Drug class	Neurosteroid
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone;
Chemical and physical data
Formula	C22H36O2
Molar mass	332.528 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@](C4)(C)O)C)C;
	InChI InChI=1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1 ; Key:PGTVWKLGGCQMBR-FLBATMFCSA-N ;
	(what is this?) (verify)

Ganaxolone, sold under the brand name Ztalmy, is a medication used to treat seizures in people with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD).^[1] It may be used in those who are at least 2 years old.^[1] It is taken by mouth.^[1]

Common side effects include sleepiness, fever, increased saliva, and seasonal allergies.^[1] Other side effects may include suicidal thoughts.^[1] It is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator.^[1]

Ganaxolone was approved for medical use in the United States in 2022.^[1] It is an orphan drug in Europe and not approved in the United Kingdom as of 2022.^[2] In the United States it costs about 133,000 USD for a person who is around 4.5 years old as of 2022.^[2]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "DailyMed - ZTALMY- ganaxolone suspension". dailymed.nlm.nih.gov. Archived from the original on 12 December 2022. Retrieved 11 December 2022.
^ ^a ^b "Ganaxolone". SPS - Specialist Pharmacy Service. 17 September 2020. Archived from the original on 25 September 2021. Retrieved 11 December 2022.

[PI2022-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j "DailyMed - ZTALMY- ganaxolone suspension". dailymed.nlm.nih.gov. Archived from the original on 12 December 2022. Retrieved 11 December 2022.

[SPS2022-2] "Ganaxolone". SPS - Specialist Pharmacy Service. 17 September 2020. Archived from the original on 25 September 2021. Retrieved 11 December 2022.

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